Document Detail


A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits.
MedLine Citation:
PMID:  1505197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A "Soft" corticosteroid, loteprednol etabonate I, designed based on the "inactive metabolite" concept can be used as a safe ophthalmic anti-inflammatory drug. By design, the metabolism of I follows a predicted biotransformation pathway, thus unwanted systemic side effects are avoided. Local side effects are also reduced. Accordingly, in a cross-over study I did not elevate the intraocular pressure (IOP) in rabbits, as opposed to dexamethasone.
Authors:
N Bodor; N Bodor; W M Wu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  11     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-09-21     Completed Date:  1992-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-30     Citation Subset:  IM    
Affiliation:
Center for Drug Discovery, J.Hillis Miller Health Center, College of Pharmacy, University of Florida, Gainesville 32610.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Androstadienes / administration & dosage,  pharmacology*
Animals
Anti-Inflammatory Agents / pharmacology*
Dexamethasone / administration & dosage,  pharmacology*
Intraocular Pressure / drug effects*
Rabbits
Tonometry, Ocular
Chemical
Reg. No./Substance:
0/Androstadienes; 0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone; 82034-46-6/loteprednol etabonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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