Document Detail


A comparison of intraarterial carboplatin and ACNU for the treatment of gliomas.
MedLine Citation:
PMID:  7502204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intraarterial chemotherapy with carboplatin for malignant gliomas has been tried recently, but its therapeutic efficacy and toxicity have not yet been elucidated. METHODS: We treated patients with malignant glioma by intraarterial chemotherapy using carboplatin, and compared the efficacy as well as the side effects with intraarterial ACNU. RESULTS: Twenty patients were treated with carboplatin (300 mg/m2) and 22 patients were treated with ACNU (80-200 mg/m2). Response (complete remission+partial response) rate for carboplatin was 12.5% compared to 45% for ACNU. Despite higher response rate for ACNU, the difference in the survival curves of the two groups was not significant. Three patients who were treated with high dose (150-200 mg/m2) of ACNU developed hemiparesis and aphasia. Seven patients treated with carboplatin developed 10 incidences of neurotoxicities; two hemiparesis, one aphasia, one blindness, one visual field disturbance, three convulsions, and two developed incidences of disturbances of consciousness. CONCLUSIONS: Intraarterial carboplatin was not superior to intraarterial ACNU in achieving remissions, and showed much greater tendency to produce neurotoxicities.
Authors:
T Fujiwara; Y Matsumoto; Y Honma; H Kuyama; S Nagao; M Ohkawa
Related Documents :
15015784 - Second-line chemotherapy with the association of liposomal daunorubicin, carboplatin an...
17429624 - A case of drug resistant clear cell ovarian cancer showing responsiveness to gemcitabin...
1329224 - Use of carboplatin in germ cell tumors of the testis.
11707654 - Phase i-ii study of neoadjuvant chemoradiotherapy followed by radical surgery in locall...
16419424 - Eyelid skin involvement in pemphigus foliaceus.
2674084 - Polyclonal 90yttrium labeled antiferritin for refractory hodgkin's disease.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  44     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-17     Completed Date:  1996-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, Kagawa Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Carboplatin / therapeutic use*
Child
Drug Therapy*
Female
Follow-Up Studies
Glioma / therapy*
Humans
Male
Middle Aged
Nimustine / adverse effects*,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
41575-94-4/Carboplatin; 42471-28-3/Nimustine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of brain tumors using 1H magnetic resonance spectroscopy.
Next Document:  Experimental study of intraoperative local chemotherapy with fibrin glue containing nitrosourea for ...