Document Detail

A comparison of intraarterial carboplatin and ACNU for the treatment of gliomas.
MedLine Citation:
PMID:  7502204     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intraarterial chemotherapy with carboplatin for malignant gliomas has been tried recently, but its therapeutic efficacy and toxicity have not yet been elucidated. METHODS: We treated patients with malignant glioma by intraarterial chemotherapy using carboplatin, and compared the efficacy as well as the side effects with intraarterial ACNU. RESULTS: Twenty patients were treated with carboplatin (300 mg/m2) and 22 patients were treated with ACNU (80-200 mg/m2). Response (complete remission+partial response) rate for carboplatin was 12.5% compared to 45% for ACNU. Despite higher response rate for ACNU, the difference in the survival curves of the two groups was not significant. Three patients who were treated with high dose (150-200 mg/m2) of ACNU developed hemiparesis and aphasia. Seven patients treated with carboplatin developed 10 incidences of neurotoxicities; two hemiparesis, one aphasia, one blindness, one visual field disturbance, three convulsions, and two developed incidences of disturbances of consciousness. CONCLUSIONS: Intraarterial carboplatin was not superior to intraarterial ACNU in achieving remissions, and showed much greater tendency to produce neurotoxicities.
T Fujiwara; Y Matsumoto; Y Honma; H Kuyama; S Nagao; M Ohkawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  44     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-17     Completed Date:  1996-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Neurological Surgery, Kagawa Medical School, Japan.
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MeSH Terms
Carboplatin / therapeutic use*
Drug Therapy*
Follow-Up Studies
Glioma / therapy*
Middle Aged
Nimustine / adverse effects*,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
41575-94-4/Carboplatin; 42471-28-3/Nimustine

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