Document Detail

A comparison of the induction characteristics of sevoflurane and halothane in children.
MedLine Citation:
PMID:  8694204     Owner:  NLM     Status:  MEDLINE    
The induction characteristics of sevoflurane and halothane were compared in 81 children aged 6 months to 6 years. The mean time taken to achieve loss of eyelash reflex was significantly shorter with sevoflurane than with halothane (sevoflurane, mean time (SD) 1 min 41 s (35 s), halothane, mean time (SD) 2 min 17 s (43 s), t = 4.11, p = < 0.01). The mean time taken to complete induction (to achieve steady spontaneous ventilation and small pupils with central gaze) was also shorter in children induced with sevoflurane (sevoflurane, mean time (SD) 3 min 58 s (1 min 8 s), halothane, mean time (SD) 4 min 50 s, (1 min 27 s), t = 2.29, p = 0.027). Effects on heart rate, blood pressure and oxygen saturation during induction were similar for both agents. There were no major complications during induction with either halothane or sevoflurane.
A Black; M R Sury; L Hemington; R Howard; A Mackersie; D J Hatch
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  51     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-26     Completed Date:  1996-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  539-42     Citation Subset:  AIM; IM    
Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London.
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MeSH Terms
Anesthesia, Inhalation / methods
Anesthetics, Inhalation*
Blood Pressure / drug effects
Child, Preschool
Consciousness / drug effects
Heart Rate / drug effects
Methyl Ethers*
Oxygen / blood
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Ethers; 0/Methyl Ethers; 151-67-7/Halothane; 28523-86-6/sevoflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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