Document Detail

A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
MedLine Citation:
PMID:  9230328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the use of ibuprofen with the use of acetaminophen with codeine for posttonsillectomy management. BACKGROUND: We were not satisfied with our traditional pain-management practice for tonsillectomy patients. We hoped to find a new approach for improved patient comfort and avoid scheduled, abusable drugs such as codeine. DESIGN: Intervention, prospective, randomized control trial. Follow-up was 1 month. SETTING: University referral center; institutional pediatric practice, ambulatory. PATIENTS: 110 children undergoing tonsillectomy with or without other procedures. Consecutive patients were offered participation. Enrollees were randomly assigned to one of two classes and analyzed with the initial assignment. No patients withdrew for adverse effects, although 12 in group 2 used codeine and 5 of those used acetaminophen, whereas 2 in group 1 received ibuprofen. INTERVENTIONS: Patients received either acetaminophen with codeine (group 1) or ibuprofen (group 2) for postoperative pain control. MAIN OUTCOME MEASURES: The main outcomes, determined before initiation of the study, were assessment of (1) postoperative bleeding, (2) pain, (3) efficacy of relief of pain by drug, (4) nausea, (5) emesis, (6) readmission to hospital, (7) average temperature, and (8) highest temperature after surgery. RESULTS: The only statistically significant difference is less nausea in patients receiving ibuprofen (p = 0.0049). Of note, no difference existed in postoperative bleeding, pain, or temperature control. CONCLUSIONS: Ibuprofen is at least as effective as acetaminophen with codeine for postoperative pain control in children after tonsillectomy.
C S St Charles; B H Matt; M M Hamilton; B P Katz
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  117     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-07     Completed Date:  1997-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Indiana University Medical Center, Indianapolis, USA.
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MeSH Terms
Acetaminophen / therapeutic use*
Analgesics, Non-Narcotic / therapeutic use*
Analgesics, Opioid / therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Child, Preschool
Codeine / therapeutic use*
Drug Combinations
Fever / drug therapy
Ibuprofen / therapeutic use*
Pain Measurement
Pain, Postoperative / drug therapy*,  etiology
Postoperative Complications / drug therapy
Prospective Studies
Tonsillectomy / adverse effects*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Drug Combinations; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen; 76-57-3/Codeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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