Document Detail

A comparison of four serum markers of fibrosis in the diagnosis of cirrhosis.
MedLine Citation:
PMID:  9133247     Owner:  NLM     Status:  MEDLINE    
C-terminal peptide of procollagen I, N-terminal peptide of procollagen III, collagen IV and serum prolyl hydroxylase were measured in 100 patients with cirrhosis and 71 patients with noncirrhotic chronic liver disease. Patients with cirrhosis had significantly higher mean values of prolyl hydroxylase, collagen IV, N-terminal peptide of procollagen III and C-terminal peptide of procollagen I as compared to noncirrhotic patients. This difference was maintained for collagen products even after stratification for alcohol intake, although all markers of fibrosis were higher in alcoholics. Stepwise logistic regression analysis showed that collagen IV, and N-terminal peptide of procollagen III were independently associated with cirrhosis. Receiver-operating characteristic (ROC) curves showed that collagen IV and N-terminal peptide of procollagen III perform more efficiently than C-terminal peptide of procollagen I and prolyl hydroxylase in identifying cirrhosis.
C Fabris; E Falleti; E Federico; P Toniutto; M Pirisi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  34 ( Pt 2)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Department of Clinical and Experimental Pathology and Medicine, University of Udine, Italy.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood*
Liver Cirrhosis / blood,  diagnosis*
Middle Aged
Peptide Fragments / blood
Procollagen / blood,  chemistry
Procollagen-Proline Dioxygenase / blood
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/Procollagen; EC Dioxygenase

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