Document Detail

A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta.
MedLine Citation:
PMID:  17000789     Owner:  NLM     Status:  MEDLINE    
Fenoldopam, a selective dopamine-1-receptor agonist, decreases arterial blood pressure rapidly, with a brief duration of action similar to sodium nitroprusside (SNP), but in contrast to SNP, it increases renal blood flow. We compared the hemodynamic and renal effects of fenoldopam in patients undergoing abdominal aortic surgery requiring cross-clamping of the aorta with another therapeutic option, dopamine and SNP. Fenoldopam or 2 mcg x kg(-1) x min(-1) of dopamine and SNP was infused before incision in 60 randomly selected patients in a double-blind fashion. Hemodynamic variables were recorded before incision, immediately before clamping the aorta, 5 min after cross-clamp release and upon completion of surgery. Urine output, serum creatinine, and creatinine clearance were measured intraoperatively and postoperatively. Characteristics were compared between groups using two-sample rank sum test for continuous variables and Fisher's exact test for discrete variables. The occurrence of severe hypotension, maximum systolic blood pressure, and need for additional antihypertensive drugs were not different between the groups. Most intraoperative hemodynamic variables and all indices of renal function did not differ according to treatment. Therefore, fenoldopam has no therapeutic advantage compared with similar therapies in patients undergoing major vascular surgery involving cross-clamping of the aorta.
William C Oliver; Gregory A Nuttall; Kenneth J Cherry; Paul A Decker; Thomas Bower; Mark H Ereth
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  103     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-26     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  833-40     Citation Subset:  AIM; IM    
Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
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MeSH Terms
Aged, 80 and over
Anesthesia / methods
Antihypertensive Agents / therapeutic use*
Aorta, Abdominal / surgery*
Blood Pressure / drug effects
Dopamine / therapeutic use*
Double-Blind Method
Fenoldopam / therapeutic use*
Heart Rate / drug effects
Kidney / blood supply,  drug effects
Middle Aged
Nitroprusside / therapeutic use*
Vascular Surgical Procedures / methods*
Reg. No./Substance:
0/Antihypertensive Agents; 15078-28-1/Nitroprusside; 67227-56-9/Fenoldopam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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