| A comparison of experimental pathogenicity of Candida species in cyclophosphamide-immunodepressed mice. | |
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MedLine Citation:
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PMID: 6505914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The experimental pathogenicity of Candida albicans, C. krusei, C. guilliermondii, C. parapsilosis, C. tropicalis and C. viswanathii was tested in normal and in cyclophosphamide-(Cy) immunodepressed mice. In unpretreated CD1 mice only C. albicans, C. tropicalis and C. viswanathii were pathogenic on intravenous challenge, with LD50 of 1.0 X 10(6), 4.8 X 10(6), 7.2 X 10(8) cells, respectively, per kg. Three days after a single intraperitoneal injection of Cy (150 mg kg-1) mice had a marked decrease in spleen weight and cellularity as well as reduced numbers of circulating leukocytes. Under these conditions, there was a significant, proportional increase in pathogenicity of C. albicans, C. tropicalis and C. viswanathii but the animals were still resistant to challenge with C. krusei, C. guilliermondii and C. parapsilosis. This pattern of susceptibility was not influenced by higher doses of Cy. Only C. albicans and C. tropicalis were capable of rapid and extensive multiplication in target organs such as kidney and brain in normal and Cy-treated mice and for both these species of Candida, there was a 'rebound' effect of increased resistance to experimental infection after 12 days from Cy administration. This study shows that the strong immunodepression provoked by Cy does not modify significantly the susceptibility of the animal to those species of Candida which were endowed with low or no pathogenicity for normal mice, but it greatly increases the susceptibility to those species of Candida that are already pathogenic for unmodified host. |
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Authors:
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F Bistoni; A Vecchiarelli; E Cenci; G Sbaraglia; S Perito; A Cassone |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Sabouraudia Volume: 22 ISSN: 0036-2174 ISO Abbreviation: Sabouraudia Publication Date: 1984 |
Date Detail:
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Created Date: 1985-01-09 Completed Date: 1985-01-09 Revised Date: 2007-04-30 |
Medline Journal Info:
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Nlm Unique ID: 0417341 Medline TA: Sabouraudia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 409-18 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / microbiology Candida / growth & development, pathogenicity* Candidiasis / etiology*, immunology Cyclophosphamide / pharmacology* Disease Susceptibility Immunosuppression Kidney / microbiology Male Mice Mice, Inbred Strains Species Specificity |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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