Document Detail


A comparison of epithelial-to-mesenchymal transition and re-epithelialization.
MedLine Citation:
PMID:  22863788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wound healing and cancer metastasis share a common starting point, namely, a change in the phenotype of some cells from stationary to motile. The term, epithelial-to-mesenchymal transition (EMT) describes the changes in molecular biology and cellular physiology that allow a cell to transition from a sedentary cell to a motile cell, a process that is relevant not only for cancer and regeneration, but also for normal development of multicellular organisms. The present review compares the similarities and differences in cellular response at the molecular level as tumor cells enter EMT or as keratinocytes begin the process of re-epithelialization of a wound. Looking toward clinical interventions that might modulate these processes, the mechanisms and outcomes of current and potential therapies are reviewed for both anti-cancer and pro-wound healing treatments related to the pathways that are central to EMT. Taken together, the comparison of re-epithelialization and tumor EMT serves as a starting point for the development of therapies that can selectively modulate different forms of EMT.
Authors:
Philip L Leopold; Jan Vincent; Hongjun Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-31
Journal Detail:
Title:  Seminars in cancer biology     Volume:  22     ISSN:  1096-3650     ISO Abbreviation:  Semin. Cancer Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-02-05     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  9010218     Medline TA:  Semin Cancer Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA. pleopold@stevens.edu
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology,  therapeutic use
Epithelial-Mesenchymal Transition* / drug effects
Humans
Neoplasms / drug therapy,  pathology
Re-Epithelialization* / drug effects
Signal Transduction / drug effects
Wound Healing / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
1R21 AR056416/AR/NIAMS NIH HHS; R21 AR056416/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents
Comments/Corrections

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