| A comparison of electrically induced cardiac arrest with cardiac arrest produced by coronary occlusion. | |
| | |
MedLine Citation:
|
PMID: 17134815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The present study was undertaken to compare an animal model of electrically induced VF with ischemically induced VF. In a preponderance of models of cardiac arrest and resuscitation in intact animals, ventricular fibrillation (VF) is induced by an alternating current delivered directly to the epicardium or endocardium. Yet, the applicability of such animal models has been challenged for it is not an electrical current alone but rather a current generated in the ischemic myocardium that triggers VF. Accordingly, a potentially more clinically relevant model was investigated in which spontaneous VF followed acute myocardial ischemia. METHODS: Twenty anesthetized pigs were randomized to either electrical fibrillation or myocardial ischemia following transient occlusion of the left anterior descending (LAD) coronary artery. RESULTS: VF was untreated for 7 min in both models after which mechanical ventilation and precordial compression were begun. Defibrillation was attempted after 5 min of CPR in both groups. VF appeared within 5.7+/-2.0 min of LAD occlusion. CONCLUSIONS: A significant increase in the number of post-resuscitation premature ventricular beats and recurrent VF followed ROSC and a significantly greater number of shocks was required for restoration of spontaneous circulation (ROSC) after LAD occlusion. Nevertheless, early post-resuscitation myocardial dysfunction, neurological recovery and 72 h survival were indistinguishable between the two models. |
| | |
Authors:
|
Jinglan Wang; Max Harry Weil; Wanchun Tang; Yun-Te Chang; Lei Huang |
Related Documents
:
|
18971575 - A comparison of cardiac strain among drillers of two different age groups in undergroun... 19955465 - A reduction in cardiac arrests and duration of clinical instability after implementatio... 6974585 - Is cardioplegic rearrest safe? 519665 - Cardiac consequences and treatment of disopyramide intoxication: experimental evaluatio... 3261805 - Myocardial positron tomography with n-13 ammonia in assessment of aortocoronary bypass ... 1433815 - Electrophysiologic changes before onset of ventricular tachyarrhythmias during partial ... |
Publication Detail:
|
Type: Journal Article Date: 2006-11-28 |
Journal Detail:
|
Title: Resuscitation Volume: 72 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-19 Completed Date: 2007-04-26 Revised Date: 2009-08-25 |
Medline Journal Info:
|
Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
|
Languages: eng Pagination: 477-83 Citation Subset: IM |
Affiliation:
|
The Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiopulmonary Resuscitation Coronary Stenosis / complications* Disease Models, Animal Electric Countershock / adverse effects* Heart Arrest / etiology*, therapy Male Prognosis Swine Ventricular Fibrillation / therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The 'ABC for life' programme - teaching basic life support in schools.
Next Document: Occurrence of ST-changes recorded with the STAN S21-monitor during normal and abnormal fetal heart r...