Document Detail

A comparison of electrically induced cardiac arrest with cardiac arrest produced by coronary occlusion.
MedLine Citation:
PMID:  17134815     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study was undertaken to compare an animal model of electrically induced VF with ischemically induced VF. In a preponderance of models of cardiac arrest and resuscitation in intact animals, ventricular fibrillation (VF) is induced by an alternating current delivered directly to the epicardium or endocardium. Yet, the applicability of such animal models has been challenged for it is not an electrical current alone but rather a current generated in the ischemic myocardium that triggers VF. Accordingly, a potentially more clinically relevant model was investigated in which spontaneous VF followed acute myocardial ischemia. METHODS: Twenty anesthetized pigs were randomized to either electrical fibrillation or myocardial ischemia following transient occlusion of the left anterior descending (LAD) coronary artery. RESULTS: VF was untreated for 7 min in both models after which mechanical ventilation and precordial compression were begun. Defibrillation was attempted after 5 min of CPR in both groups. VF appeared within 5.7+/-2.0 min of LAD occlusion. CONCLUSIONS: A significant increase in the number of post-resuscitation premature ventricular beats and recurrent VF followed ROSC and a significantly greater number of shocks was required for restoration of spontaneous circulation (ROSC) after LAD occlusion. Nevertheless, early post-resuscitation myocardial dysfunction, neurological recovery and 72 h survival were indistinguishable between the two models.
Jinglan Wang; Max Harry Weil; Wanchun Tang; Yun-Te Chang; Lei Huang
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Publication Detail:
Type:  Journal Article     Date:  2006-11-28
Journal Detail:
Title:  Resuscitation     Volume:  72     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-04-26     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  477-83     Citation Subset:  IM    
The Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, United States.
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MeSH Terms
Cardiopulmonary Resuscitation
Coronary Stenosis / complications*
Disease Models, Animal
Electric Countershock / adverse effects*
Heart Arrest / etiology*,  therapy
Ventricular Fibrillation / therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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