Document Detail

[A comparison of the efficacy of bupivacaine and levobupivacaine in patient-controlled epidural analgesia for postoperative pain in patients undergoing knee arthroplasty].
MedLine Citation:
PMID:  23145755     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: In this study, we aimed to compare the efficacy of bupivacaine and levobupivacaine in the patient-controlled epidural analgesia (PCEA) in patients who underwent total knee arthroplasty (TKA), particularly with cardiac diseases.
PATIENTS AND METHODS: Forty-four patients (16 males, 28 females; mean age 70.2±6.3 years; range 18 to 80 years) who were scheduled for TKA surgery under combined spinal and epidural anesthesia were included. Patients were randomly divided into two groups. Bupivacaine 15 mg 0.5% for group 1 (n=23) and levobupivacaine 15 mg 0.5% for group (n=23) were administered via spinal route. The amount of local anesthetics, PCEA starting times and bolus/demand ratio of local anesthetics were recorded. The level of pain, need for additional analgesic, total amount of analgesic, degree of motor block, complications were asked for patient satisfaction at postoperative 6, 12, 24 and 48 hours.
RESULTS: No statistical differences were determined between group 1 and group 2 in terms of the operation times, PCEA starting times, bolus number/demand ratios, visual analog scale (VAS) scores and numerical rating scores (NRS) at the postoperative 6, 12, 24 and 48 hours, need for additional analgesic, total amount of analgesic, degree of motor block and patient satisfaction. Although the incidence of side effects was lower in the group 1 compared to group 2, it was not statistically significant.
CONCLUSION: We concluded that it would be proper using levobupivacaine rather than bupivakaine for patients with cardiac diseases, as the cardiotoxic and neurotoxic effects of levobupivacaine is lower then bupivacaine with a similar analgesic efficacy.
Ali Sızlan; Abdulkadir Atım; Yüksel Yurttaş; Hüseyin Ozkan; Meltem Bilge; Murat Kuyumcu; Cemil Yıldız; Ercan Kurt; Mustafa Başbozkurt
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery     Volume:  23     ISSN:  1309-0313     ISO Abbreviation:  Eklem Hastalik Cerrahisi     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265191     Medline TA:  Eklem Hastalik Cerrahisi     Country:  Turkey    
Other Details:
Languages:  tur     Pagination:  134-9     Citation Subset:  IM    
Department of Anesthesiology and Reanimation, Gülhane Military Medical Academy, 06018 Etlik, Ankara, Turkey.
Vernacular Title:
Diz artroplastisi yapılan hastalarda ameliyat sonrası ağrı için hasta kontrollü epidural analjezide bupivakain ve levobupivakainin etkinliğinin karşılaştırılması
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