Document Detail


A comparison of effects of thermal injury and smoke inhalation on bacterial translocation.
MedLine Citation:
PMID:  2352293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thermal injury as well as smoke inhalation injury results in serious morbidity and high mortality. In a chronic ovine model, we studied the development of bacterial translocation to the mesenteric lymph node, liver, spleen, kidney, and lung following: 1) sham injury (N = 6), 2) cutaneous thermal injury (N = 5), 3) cotton smoke inhalation injury (N = 4), 4) combined thermal injury and smoke inhalation injury (N = 7). Cardiac output, mean arterial pressure, and plasma protein concentration were maintained within 10% of preinjury values. Urine output was maintained above 1 ml/kg/hour with fluid and plasma resuscitation. A wide-beam ultrasonic flow probe was chronically implanted to allow serial measurement of cephalic mesenteric arterial blood flow throughout the 48-hour experimental period. Sheep were sacrificed 48 hours following injury for quantitative organ culture of mesenteric lymph node, liver, spleen, kidney, and lung. Measurements of mesenteric blood flow demonstrated a decrease to 48 +/- 8%, 80 +/- 5%, and 64 +/- 9% of preinjury levels in sheep receiving thermal injury, smoke inhalation injury, and combination injury, respectively. The sham animals maintained mesenteric blood flow at 102 +/- 7% of control levels. Thermal injury, as well as combination thermal and smoke inhalation injury, resulted in higher levels of translocation than smoke inhalation injury alone.
Authors:
S E Morris; N Navaratnam; D N Herndon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  30     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-19     Completed Date:  1990-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  639-43; discussion 643-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Shriners Burns Institute, University of Texas Medical Branch, Galveston.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / growth & development
Burns / microbiology*,  physiopathology
Cardiac Output
Kidney / microbiology
Liver / microbiology
Lung / microbiology
Lymph Nodes / microbiology
Mesenteric Arteries / physiopathology
Sheep
Smoke Inhalation Injury / microbiology*,  physiopathology
Splanchnic Circulation
Spleen / microbiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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