| A comparison of effects of thermal injury and smoke inhalation on bacterial translocation. | |
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MedLine Citation:
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PMID: 2352293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thermal injury as well as smoke inhalation injury results in serious morbidity and high mortality. In a chronic ovine model, we studied the development of bacterial translocation to the mesenteric lymph node, liver, spleen, kidney, and lung following: 1) sham injury (N = 6), 2) cutaneous thermal injury (N = 5), 3) cotton smoke inhalation injury (N = 4), 4) combined thermal injury and smoke inhalation injury (N = 7). Cardiac output, mean arterial pressure, and plasma protein concentration were maintained within 10% of preinjury values. Urine output was maintained above 1 ml/kg/hour with fluid and plasma resuscitation. A wide-beam ultrasonic flow probe was chronically implanted to allow serial measurement of cephalic mesenteric arterial blood flow throughout the 48-hour experimental period. Sheep were sacrificed 48 hours following injury for quantitative organ culture of mesenteric lymph node, liver, spleen, kidney, and lung. Measurements of mesenteric blood flow demonstrated a decrease to 48 +/- 8%, 80 +/- 5%, and 64 +/- 9% of preinjury levels in sheep receiving thermal injury, smoke inhalation injury, and combination injury, respectively. The sham animals maintained mesenteric blood flow at 102 +/- 7% of control levels. Thermal injury, as well as combination thermal and smoke inhalation injury, resulted in higher levels of translocation than smoke inhalation injury alone. |
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Authors:
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S E Morris; N Navaratnam; D N Herndon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of trauma Volume: 30 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-19 Completed Date: 1990-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 639-43; discussion 643-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Shriners Burns Institute, University of Texas Medical Branch, Galveston. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / growth & development Burns / microbiology*, physiopathology Cardiac Output Kidney / microbiology Liver / microbiology Lung / microbiology Lymph Nodes / microbiology Mesenteric Arteries / physiopathology Sheep Smoke Inhalation Injury / microbiology*, physiopathology Splanchnic Circulation Spleen / microbiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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