Document Detail


A comparison of the effects of parathyroid hormone and parathyroid hormone-related protein on osteocalcin in the rat.
MedLine Citation:
PMID:  7572314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the effects of parathyroid hormone (PTH1-34) and parathyroid hormone-related protein (PTHrp1-34) on osteocalcin release in the isolated rat hindlimb and in intact and thyroparathyroidectomized (TPTX) rats. PTH1-34 suppressed osteocalcin release from perfused rat hindquarters, while PTHrp1-34 had no effect on osteocalcin release, despite comparable stimulation of cAMP production. Similarly, serum osteocalcin declined in the intact and TPTX animals by 5 h after a single dose of PTH1-34, while there was no response to PTHrp1-34. Chronic administration of PTH1-34 or PTHrp1-34 produced comparable hypercalcemia and hypophosphatemia in sham-operated and TPTX animals. Chronic PTH1-34 administration produced significant increases in serum osteocalcin both in the sham-operated rats and in the TPTX animals. However, in animals chronically treated with PTHrp1-34, there was no change at any time point in osteocalcin in either sham-operated or TPTX rats. These differences could be inherent or merely due to potency differences between the two peptides.
Authors:
C M Gundberg; M I Fawzi; M E Clough; M S Calvo
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  10     ISSN:  0884-0431     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-26     Completed Date:  1995-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  903-9     Citation Subset:  IM    
Affiliation:
Department of Orthopaedics, Yale University School of Medicine, New Haven, Connecticut, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Computer Simulation
Cyclic AMP / metabolism
Hindlimb / drug effects,  metabolism
Hypercalcemia / chemically induced
Hypophosphatemia / chemically induced
Infusion Pumps, Implantable
Male
Osteocalcin / blood*,  metabolism
Parathyroid Hormone / administration & dosage,  pharmacology*
Parathyroid Hormone-Related Protein
Parathyroidectomy
Peptide Fragments / administration & dosage,  pharmacology*
Perfusion
Proteins / administration & dosage,  pharmacology*
Radioimmunoassay
Rats
Rats, Sprague-Dawley
Teriparatide
Grant Support
ID/Acronym/Agency:
AR01789/AR/NIAMS NIH HHS; R01-AR38460/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 0/Parathyroid Hormone-Related Protein; 0/Peptide Fragments; 0/Proteins; 104982-03-8/Osteocalcin; 52232-67-4/Teriparatide; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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