Document Detail

A comparison of the effects of isoflurane and desflurane on the neuromuscular effects of mivacurium.
MedLine Citation:
PMID:  8694206     Owner:  NLM     Status:  MEDLINE    
The effects of 1 MAC of desflurane and isoflurane (in 66% nitrous oxide) on the potency and duration of action of mivacurium were studied in 80 patients. The ED95 of mivacurium was 86 (74-100) and 88 (76-103) (mean and 95% confidence intervals) during anaesthesia with desflurane and isoflurane respectively. The onset and duration of recovery to 25, 75 and 90% of T1 (first response in the TOF) of 200 of mivacurium were 1.4 (0.3) and 1.5 (0.3) min (mean and SD), 22 (4.9) and 19 (4.0), 29 (6.6) and 26 (5.8), and 32 (7.3) and 29 (6.6) min respectively. There was no significant difference in any of the variables between desflurane and isoflurane. It is concluded that the neuromuscular effects of mivacurium are similar during anaesthesia with 1 MAC of desflurane and isoflurane.
N Kumar; R K Mirakhur; M J Symington; P B Loan; F M Connolly
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  51     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-26     Completed Date:  1996-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  AIM; IM    
Department of Anaesthetics, Queen's University of Belfast.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Isoflurane / analogs & derivatives*,  pharmacology*
Isoquinolines / pharmacology*
Middle Aged
Neuromuscular Junction / drug effects
Neuromuscular Nondepolarizing Agents / pharmacology*
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 106791-40-6/mivacurium; 26675-46-7/Isoflurane; 57041-67-5/desflurane

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