Document Detail

A comparison of the effects of dopexamine and prostacyclin in systemic inflammatory response syndrome.
MedLine Citation:
PMID:  10455827     Owner:  NLM     Status:  MEDLINE    
Forty critically ill patients fulfilling the definitions of systemic inflammatory response syndrome were enrolled in a double-blind cross-over interventional study assessing the effects of dopexamine and prostacyclin on splanchnic perfusion, cardiovascular function and oxygen flux. The cross-over design involved either dopexamine (1.25 or prostacyclin (0.5 being infused for 6 h followed by a 12-h washout period prior to an identical infusion sequence using the other agent. Preliminary analysis revealed a significant period effect, so data from the second infusion period were excluded from further analysis. Dopexamine caused a significant increase in heart rate (116 vs. 106 beat.min-1), and urine output (103 vs. 69 ml.h-1). Dopexamine produced a significant increase in oxygen delivery (infusion 548 ml O2.min-1.m-2; no infusion 492 ml O2.min-1.m-2) while prostacyclin caused a decrease (infusion 460 ml O2.min-1.m-2; no infusion 547 ml O2.min-1.m-2). The results indicate that dopexamine improves oxygen delivery and urine output more effectively than prostacyclin.
M Blunt; P Young; S Ridley
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  54     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-08-30     Completed Date:  1999-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  313-9     Citation Subset:  AIM; IM    
Norfolk & Nonvich Hospital, UK.
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MeSH Terms
Adrenergic beta-Agonists / therapeutic use
Aged, 80 and over
Cross-Over Studies
Dopamine / analogs & derivatives*,  therapeutic use
Double-Blind Method
Epoprostenol / therapeutic use*
Hemodynamics / drug effects
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use*
Splanchnic Circulation / drug effects
Systemic Inflammatory Response Syndrome / drug therapy*,  physiopathology
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Platelet Aggregation Inhibitors; 0/Vasodilator Agents; 35121-78-9/Epoprostenol; 86197-47-9/dopexamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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