Document Detail

A comparison of the effects of corticotropin releasing factor and sauvagine on food intake.
MedLine Citation:
PMID:  6359178     Owner:  NLM     Status:  MEDLINE    
Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.
B A Gosnell; J E Morley; A S Levine
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  19     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  771-5     Citation Subset:  IM    
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MeSH Terms
Amphibian Proteins
Corticotropin-Releasing Hormone / pharmacology*
Cyclazocine / analogs & derivatives,  pharmacology
Feeding Behavior / drug effects*
Food Deprivation
Peptide Hormones
Peptides / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Amphibian Proteins; 0/Peptide Hormones; 0/Peptides; 3572-80-3/Cyclazocine; 58640-84-9/Ethylketocyclazocine; 74434-59-6/sauvagine; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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