Document Detail


A comparison of the effectiveness of waxed paper and Gore-Tex on the minimally invasive epidural fibrosis model.
MedLine Citation:
PMID:  19190435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY DESIGN: Experimental animal study. OBJECTIVE: The authors conducted a study to determine the effectiveness of waxed paper in preventing postlaminectomy epidural fibrosis in rats. SUMMARY OF BACKGROUND DATA: Extensive epidural fibrosis after lumbar surgery may be the underlying cause in most cases of failed back surgery syndrome. Various materials have been used to prevent epidural fibrosis, but only moderate success has been shown. METHODS: Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Waxed paper or Gore-Tex was applied in a blinded fashion to the operative sites. In the control group, only the L-4 laminectomy was performed. The rats were killed 28 days after surgery. RESULTS: The extent of epidural fibrosis was evaluated by histologic analysis. There was a meaningful statistical difference among the waxed paper group and the Gore-Tex group compared with the control group, but there was no difference when the effectiveness of waxed paper was compared with that of Gore-Tex. CONCLUSIONS: In this experimental model, the waxed paper applied locally effectively reduced epidural fibrosis, completely avoided dural adherence, and induced no side effects.
Authors:
Gokhan Kurt; Bulent Celik; Berker Cemil; Fikret Doğulu; Mustafa Kemali Baykaner; Necdet Ceviker
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of spinal disorders & techniques     Volume:  22     ISSN:  1539-2465     ISO Abbreviation:  J Spinal Disord Tech     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140323     Medline TA:  J Spinal Disord Tech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal*
Epidural Space / pathology*,  surgery
Female
Fibrosis
Laminectomy / adverse effects
Lumbar Vertebrae / pathology,  surgery
Polytetrafluoroethylene / administration & dosage*
Postoperative Complications / etiology,  pathology,  prevention & control
Rats
Rats, Sprague-Dawley
Surgical Procedures, Minimally Invasive / adverse effects*
Waxes
Chemical
Reg. No./Substance:
0/Waxes; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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