Document Detail

A comparison of the effectiveness of single-dose vs multi-dose antenatal corticosteroids in pre-term neonates.
MedLine Citation:
PMID:  16368579     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to compare the outcome between exposure to single vs multiple courses of antenatal corticosteroids (AC) in pre-term births. The study involved 704 neonates delivered between 24-32 weeks. Maternal and perinatal outcome were compared between 294 (42%) neonates who received no AC; 257 (36%) who received single AC and 153 (22%) who received multiple AC. Any AC compared with no AC showed decreased composite neonatal morbidity (51% vs 62%, p = 0.004, odds ratio (OR) = 0.6), neonatal death (52% vs 62%, p = 0.004, OR = 0.6) and hyaline membrane disease (45% vs 57%, p = 0.002, OR = 0.6) with increased chorioamnionitis (17% vs 11%, p = 0.037, OR = 1.6) and pulmonary oedema (12% vs 1%, p = 0.0001, OR = 13). Multiple AC compared with single AC was associated with increased positive maternal cultures (44% vs 31%, p < or =0.005, OR = 1.8), small for gestational age infants (35% vs 21%, p = 0.001, OR = 2) and intraventricular haemorrhage (45% vs 34%, p <0.05, OR = 1.6). Multiple corticosteroid courses when compared with single corticosteroid course did not further reduce composite neonatal morbidity but increased the risk of positive maternal cultures and neonatal small for gestational age and intraventricular haemorrhage.
D Ogunyemi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  25     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  756-60     Citation Subset:  IM    
Perinatology Unit, Morristown Memorial Hospital, New Jersey, USA.
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MeSH Terms
Betamethasone / administration & dosage*
Dose-Response Relationship, Drug
Glucocorticoids / administration & dosage*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / prevention & control*
Infant, Small for Gestational Age
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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