| A comparison of the effect on QT interval between thiamylal and propofol during anaesthetic induction*. | |
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MedLine Citation:
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PMID: 20528837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SUMMARY: The aim of this study was to determine the effect of thiamylal and propofol on heart rate-corrected QT (QTc) interval during anaesthetic induction. We studied 50 patients undergoing lumbar spine surgery. Patients were administered 3 microgxkg(-1) fentanyl and were randomly allocated to receive 5 mgxkg(-1) thiamylal or 1.5 mgxkg(-1) propofol as an induction agent. Tracheal intubation was performed after vecuronium administration. Heart rate, mean arterial pressure, bispectral index score, and 12-lead electrocardiogram were recorded at the following time points: just before (T1) and 2 min after (T2) fentanyl administration; 2 min after anaesthetic administration (T3); 2.5 min after vecuronium injection (T4); and 2 min after intubation (T5). Thiamylal prolonged (p < 0.0001), but propofol shortened (p < 0.0001), the QTc interval. |
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Authors:
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U Higashijima; Y Terao; T Ichinomiya; K Miura; M Fukusaki; K Sumikawa |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-05-28 |
Journal Detail:
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Title: Anaesthesia Volume: 65 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 679-83 Citation Subset: AIM; IM |
Affiliation:
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Staff, Department of Anaesthesia, Nagasaki Rosai Hospital, Sasebo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anesthetics, Intravenous / adverse effects, pharmacology* Blood Pressure / drug effects Electrocardiography / drug effects*, methods Female Heart Rate / drug effects Humans Intraoperative Complications / chemically induced Intubation, Intratracheal / methods Long QT Syndrome / chemically induced* Lumbar Vertebrae / surgery Male Middle Aged Monitoring, Intraoperative / methods Propofol / pharmacology* Thiamylal / adverse effects, pharmacology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 2078-54-8/Propofol; 77-27-0/Thiamylal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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