| A comparison of different energy window subtraction methods to correct for scatter and downscatter in I-123 SPECT imaging. | |
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MedLine Citation:
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PMID: 22513883 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: One of the main problems in quantification of single photon emission computer tomography imaging is scatter. In iodine-123 (I-123) imaging, both the primary 159 keV photons and photons of higher energies are scattered. In this experimental study, different scatter correction methods, based on energy window subtraction, have been compared with each other. METHODS AND MATERIALS: Iodine-123 single photon emission computed tomography images of a phantom with a known intensity ratio between background and hollow spheres were acquired for three different collimators (low energy high resolution, low energy general purpose, and medium energy general purpose). The hollow spheres were filled with a higher activity concentration than the uniform background activity concentration, resulting in hot spots. Counts were collected in different energy windows, and scatter correction was performed by applying different methods such as effective scatter source estimation, triple and dual energy window (TEW and DEW), double peak window (DPW) and downscatter correction. The intensity ratio between the spheres and the background was used to compare the performance of the different methods. RESULTS: The results revealed that the efficiency of the scatter correction techniques vary depending on the collimator used. For the low energy high resolution collimator, all correction methods except the effective scatter source estimation and the DPW perform well. For the medium energy general purpose collimator, even without scatter correction, the calculated ratio is close to the real ratio. The DEW and DPW methods tend to overestimate the ratio. For the low energy general purpose collimator, only the DEW and the combined DEW and downscatter correction methods perform well. CONCLUSION: The only correction method that provides a ratio that differs by less than 5% from the real ratio for all the collimators is the combined DEW and downscatter correction method. |
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Authors:
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Vera Lagerburg; Robin de Nijs; Søren Holm; Claus Svarer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-16 |
Journal Detail:
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Title: Nuclear medicine communications Volume: - ISSN: 1473-5628 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Department of Clinical Physiology, Nuclear Medicine and PET b Neurobiology Research Unit, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark c Department of Clinical Physics, Spaarne Hospital, Hoofddorp, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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