Document Detail


A comparison of the decontamination efficacy of foam-making blends based on cationic and nonionic tensides against organophosphorus compounds determined in vitro and in vivo.
MedLine Citation:
PMID:  14580011     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of foam-making blends to decontaminate the skin exposed to organophosphorus compounds was tested. The appropriate composition and rheological features (stability, grade of foaming) of tested blends were evaluated by in vitro methods and their ability to remove the contaminants from hard surface and to transform the contaminants into nontoxic compounds was evaluated by in vivo methods. The blends containing cationic and nonionic tensides as well as alkalized hydrogen peroxide seem to be the most efficacious to decontaminate the skin exposed to organophosphorus compounds according to the literature data. The composition of tested blends was optimized because particular components often have antagonistic effects. Cationic tensides support the reactivity of the blend and control the grade of foaming. Nonionic tensides control the stability of the foams but also react as retardants of the reactivity of the foams. Hydrogen peroxide is a real reacting component when it is transformed into hydrogen peroxide anion. It also acts as buffer if pH is higher than 11. Our in vivo results confirm that Desam OX (34 and 68%) and the foam-making blend containing benzalkonium chloride--Althosan MB (8%), Slovasol 2510 (2%) and hydrogen peroxide (3%) alkalized at pH 12 seem to be the most efficacious to remove contaminants (soman, VX) from the skin and transform them into nontoxic compounds. Therefore they could be used for primary decontamination of chemical casualties contaminated with nerve agents in the field condition.
Authors:
J Cabal; J Kassa; J Severa
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  22     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2004-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
Affiliation:
Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Cations
Chemical Warfare Agents*
Decontamination / methods*
Dose-Response Relationship, Drug
Hydrogen Peroxide / administration & dosage,  chemistry,  pharmacology
Lethal Dose 50
Male
Organothiophosphorus Compounds / administration & dosage,  antagonists & inhibitors*,  toxicity
Rats
Rats, Wistar
Soman / administration & dosage,  antagonists & inhibitors*,  toxicity
Surface-Active Agents / administration & dosage,  chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Cations; 0/Chemical Warfare Agents; 0/Organothiophosphorus Compounds; 0/Surface-Active Agents; 50782-69-9/VX; 7722-84-1/Hydrogen Peroxide; 96-64-0/Soman

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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