Document Detail

A comparison of coding sequence and cytogenetic localization of the myostatin gene in the dog, red fox, arctic fox and Chinese raccoon dog.
MedLine Citation:
PMID:  20016167     Owner:  NLM     Status:  MEDLINE    
The gene encoding myostatin (MSTN), due to its crucial function for growth of skeletal muscle mass, is an important candidate for muscularity. In this study we analyzed the nucleotide sequence and FISH localization of this gene in 4 canids, including 3 farm species. The nucleotide sequence of the MSTN coding fragment turned out to be highly conserved, since its identity among the studied species was very high and varied between 99.4 and 99.7%. Only 1, widely spread, silent single nucleotide polymorphism (SNP) was found in exon 1 of the Chinese raccoon dog. The MSTN gene was localized close to the centromere in one-armed chromosomes of the dog (37q11) and bi-armed chromosomes of the red fox (16p11) and arctic fox (10q11), with an exception of the Chinese raccoon dog chromosome (2q14-q21). This chromosome is orthologous to 3 canine chromosomes and thus the MSTN was found more interstitially. Our results are in agreement with the hypothesis that karyotypes of the canids evolved mainly through centric fusion/fission events, while tandem fusions occurred rarely.
M Grzes; J Nowacka-Woszuk; I Szczerbal; J Czerwinska; J Gracz; M Switonski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-09
Journal Detail:
Title:  Cytogenetic and genome research     Volume:  126     ISSN:  1424-859X     ISO Abbreviation:  Cytogenet. Genome Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142708     Medline TA:  Cytogenet Genome Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Poznan University of Life Sciences, Poznan, Poland.
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MeSH Terms
Base Sequence
Canidae / genetics*
Cytogenetic Analysis*
DNA Primers
In Situ Hybridization, Fluorescence
Myostatin / genetics*
Species Specificity
Reg. No./Substance:
0/DNA Primers; 0/Myostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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