| A comparison of clinical findings of familial Mediterranean fever patients with and without amyloidosis. | |
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MedLine Citation:
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PMID: 15290087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study investigates the clinical and demographic characteristics of familial Mediterranean fever (FMF) patients with and without amyloidosis. PATIENTS AND METHODS: The clinical data of 503 patients with FMF (females:males 250:253) were reviewed. Fifty of these patients had amyloidosis (f:m 23:27). RESULTS: The ages of attack onset in patients with and without amyloidosis were 7.8+/-6.2 and 11.1+/-8.5, respectively (P<0.05). The time between disease onset and diagnosis was longer in patients with amyloidosis than those without (187.6+/-99.4 months and 132.5+/-110.2 months, respectively, P<0.001). More patients in the amyloidosis group had positive family histories of FMF (68% vs 54%, P<0.05). The frequencies of chest pain (78% vs 51%, P<0.001), arthritis ( 80% vs 60%, P<0.01), and erysipelas-like erythema (44% vs 16%, P<0.001) were higher in the amyloidosis group. CONCLUSION: In the amyloidosis group, FMF-related manifestations of chest pain, arthritis, and erysipelas-like erythema are more frequent. Our results also support that long periods between disease onset and diagnosis are associated with a high risk of developing amyloidosis. |
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Authors:
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Ayse Cefle; Sevil Kamali; Mehmet Sayarlioglu; Murat Inanc; Lale Ocal; Orhan Aral; Meral Konice; Ahmet Gul |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2004-07-30 |
Journal Detail:
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Title: Rheumatology international Volume: 25 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-09-05 Completed Date: 2005-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 442-6 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Division of Internal Medicine, Istanbul University Faculty of Medicine, Istanbul, Turkey. kcefle@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Amyloidosis / epidemiology, etiology*, pathology Arthritis / complications, epidemiology, pathology Chest Pain / complications, etiology, pathology Child Child, Preschool Erysipelas / complications, epidemiology, pathology Erythema / complications, epidemiology, pathology Familial Mediterranean Fever / complications*, epidemiology, pathology Female Humans Infant Kidney Failure, Chronic / epidemiology, etiology, pathology Male Proteinuria / diagnosis, etiology Time Factors Turkey / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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