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A comparison of clinical findings between histologically confirmed type 1 and type 2 autoimmune pancreatitis.
MedLine Citation:
PMID:  21929653     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Aim: Type 2 autoimmune pancreatitis (AIP) has been reported mainly in Western countries and is thought to be very rare in Asia. The aim of this study was to compare the prevalence, clinical profiles, detailed radiological findings, and steroid responsiveness between type 1 and type 2 AIP in Korea. Methods: From 120 patients diagnosed with AIP between January 2003 and August 2010, 52 patients with histologically confirmed type 1 (n=37) or type 2 (n=15) AIP were included. Results: The median age of patients with type 2 AIP was significantly lower than that of patients with type 1 AIP (61 vs. 34 years, p<0.05). At initial presentation, severe abdominal pain and presentation with acute pancreatitis were more frequent in patients with type 2 AIP (p<0.05). On CT scan, the extent of pancreatic enlargement and the frequency of low-density mass did not differ significantly between the two groups. The detailed pancreatographic findings on ERCP/MRCP were not significantly different between the two groups. All patients with steroids therapy improved clinically and radiologically in response (25/25 in type 1 AIP and 14/14 in type 2 AIP). During the follow-up period, none of the patients with type 2 AIP experienced relapse. Conclusions: Type 2 AIP in all histologically confirmed AIP cases in Korea may not be as rare as originally thought, with an estimated 28.8% (15/52) of prevalence rate. The detailed radiological findings of type 1 and type 2 AIP were not significantly different, and both subtypes responded well to steroids.
Authors:
Tae Jun Song; Ji Hoon Kim; Myung-Hwan Kim; Ji Woong Jang; Do Hyun Park; Sang Soo Lee; Dong Wan Seo; Sung Koo Lee; Eunsil Yu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Internal Medicine, Inje University Ilsan Paik Hospital, Koyang, Korea Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
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