| A comparison of clindamycin phosphate 1 percent topical lotion and placebo in the treatment of acne vulgaris. | |
| | |
MedLine Citation:
|
PMID: 2945704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The efficacy and skin tolerance of 1 percent clindamycin phosphate lotion were compared with those of the placebo for the lotion in a randomized, double-blind, 12-week study in forty-six patients with moderate to severe acne vulgaris. Patients using the 1 percent clindamycin lotion experienced reductions in numbers of pustules, papules, open comedones, and nodulocystic lesions. Papule counts were also reduced in placebo-treated patients. The group using clindamycin lotion had significantly greater reductions in pustule counts at week 12 and papule counts at week 3 than the placebo-treated group. Nearly 90 percent of the evaluable patients at week 12 experienced improvement or marked improvement in their acne according to the physician's evaluation, regardless of treatment group. Both regimens were well tolerated. Although diarrhea was reported by eight patients (three taking clindamycin, five receiving placebo), no patients discontinued the protocol because of diarrhea. This study demonstrated the efficacy of 1 percent clindamycin topical lotion in the treatment of moderate to severe acne vulgaris. |
| | |
Authors:
|
D S Kuhlman; J P Callen |
Related Documents
:
|
19389524 - Methotrexate and psoriasis: 2009 national psoriasis foundation consensus conference. 17085994 - Psoriasis and pentoxifylline: a clinical, histopathologic, and immunohistochemical eval... 11069504 - The prevalence and clinical characteristics of pruritus among patients with extensive p... 1103934 - Efficacy of miconazole in the topical treatment of tinea pedis in sportsmen. 20550704 - Change in depressive symptoms over higher education and professional establishment - a ... 23137714 - Thyroid function tests at delivery and risk for postpartum depressive symptoms. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Cutis; cutaneous medicine for the practitioner Volume: 38 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 1986 Sep |
Date Detail:
|
Created Date: 1986-12-03 Completed Date: 1986-12-03 Revised Date: 2013-05-08 |
Medline Journal Info:
|
Nlm Unique ID: 0006440 Medline TA: Cutis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 203-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acne Vulgaris
/
drug therapy*,
pathology Administration, Topical Adolescent Adult Clindamycin / administration & dosage, analogs & derivatives*, therapeutic use Clinical Trials as Topic Double-Blind Method Female Humans Male |
| Chemical | |
Reg. No./Substance:
|
18323-44-9/Clindamycin; 24729-96-2/clindamycin phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term results of surgical treatment of renovascular hypertension.
Next Document: Topical metronidazole in the treatment of rosacea.