| A comparison of cardiac Z-scores versus cardiac asymmetry for the prenatal screening of congenital heart disease. | |
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MedLine Citation:
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PMID: 21400625 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the best screening tests for discriminating early indicators of cardiac hypoplasia in congenital heart disease from normal variation in fetal cardiac growth. METHODS: We retrospectively examined fetal echocardiograms from 90 infants with confirmed congenital heart defects: (Group 1, n = 35) with right-sided obstructive lesions and (Group 2, n = 55) with left-sided obstructive lesions. Our control group was comprised of 2735 normal fetuses, from which we determined fetal cardiac z-scores of right ventricle (RV), left ventricle (LV), aorta (Ao) and pulmonary artery (PA) and ratios of right to left ventricle (RV/LV) and pulmonary artery to aorta (PA/Ao). We compared our normal cohort to Groups 1 and 2, using analysis of variance (ANOVA) and area under the curve (AUC) of receiver operator charteristics (ROC) analysis. RESULTS: For Group 1, RV/LV ratio, RV z-score and PA/Ao ratio were the best screening tests with highest AUC (0.879, 0.868 and 0.832, respectively). For Group 2, the Ao z-score, PA/Ao and RV/LV ratios were the best screening tests with AUC of 0.77, 0.723 and 0.716, respectively. CONCLUSION: None of the screening tests was found to be perfect early discriminators for the cardiac lesions tested. Although ratios of PA/Ao and RV/LV are useful, they should be combined with fetal cardiac z-scores to maximize screening sensitivity. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
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Authors:
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Thomas Riggs; Ashish P Saini; Christine H Comstock; Wesley Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Division of Pediatric Cardiology, Dept. of Pediatrics, Beaumont Children's Hospital, Royal Oak, MI, United States; Research Institute, Beaumont Hospital, Royal Oak, MI, United States. triggs@beaumont.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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