| A comparison of calcium pentagastrin and TRH tests in screening for medullary carcinoma of the thyroid in MEN IIA. | |
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MedLine Citation:
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PMID: 1971777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous injections of calcium gluconate and pentagastrin (CPG) or TRH were compared as secretagogues for calcitonin (CT) in screening for medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type IIA (MEN IIA). Administration of CPG resulted in a prompt increase in plasma CT in all five patients with MTC studied, one of whom had a normal baseline value (peak 412-371,000 ng/l, 636-4847% above basal). TRH produced a rise in plasma CT levels only in MTC patients with elevated basal values; the magnitude of increase was less than that observed with CPG (peak 168-17,200 ng/l, 113-180% above basal). CT levels did not rise above 300 ng/l with either test in four unaffected first-degree relatives of MEN IIA patients, three subjects with sporadic unilateral phaeochromocytomas and five controls with essential hypertension. CPG remains the CT secretagogue of choice in screening for MTC in MEN II A. |
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Authors:
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J E O'Connell; A F Dominiczak; C G Isles; A R McLellan; G Davidson; C E Gray; J M Connell |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 32 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-07-06 Completed Date: 1990-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 417-21 Citation Subset: IM |
Affiliation:
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MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcitonin / blood Calcium Gluconate / diagnostic use Carcinoma / blood, diagnosis* Female Humans Male Middle Aged Multiple Endocrine Neoplasia / blood, diagnosis* Pentagastrin / diagnostic use* Stimulation, Chemical Thyroid Neoplasms / blood, diagnosis* Thyrotropin-Releasing Hormone / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 299-28-5/Calcium Gluconate; 5534-95-2/Pentagastrin; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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