Document Detail


A comparison of buccal nitroglycerin and sublingual nitroglycerin in the prophylaxis and treatment of exertional (situation-provoked) angina pectoris.
MedLine Citation:
PMID:  1908385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Suscard is a buccally administered formulation which provides rapid introduction of nitroglycerin directly into the systemic circulation and, by virtue of its sustained-release properties, may confer protection against anginal attacks for several hours. Its efficacy has been established in angina pectoris and more recently its usefulness has been extended to include the management of unstable angina and acute heart failure. Buccal nitroglycerin combines the possibilities of short-term treatment and more extended prophylaxis. In a multicentre double-blind study the efficacy of buccal nitroglycerin and sublingual nitroglycerin were compared in patients with proven chronic stable exercise-induced angina as regards anginal attacks and capacity for physical activity. The conclusion is that the two formulations of nitroglycerin have a comparable effect in the treatment of acute attacks of angina pectoris. Buccal nitroglycerin has many advantages when used prophylactically. This is documented by less frequent anginal attacks and a more prolonged duration of effect resulting in an increased physical activity.
Authors:
C L Bray; S Jain; E B Faragher; A Myers; P Myers; P MacIntyre; A Rae; M Goldman; M Alcorn
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  European heart journal     Volume:  12 Suppl A     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-09-20     Completed Date:  1991-09-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Affiliation:
Wythenshawe Hospital, Manchester, U.K.
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MeSH Terms
Descriptor/Qualifier:
Administration, Buccal
Administration, Sublingual
Adult
Aged
Angina Pectoris / drug therapy*,  etiology,  prevention & control
Double-Blind Method
Electrocardiography
Female
Humans
Male
Middle Aged
Nitroglycerin / administration & dosage*,  therapeutic use
Physical Exertion
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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