Document Detail

A comparison of buccal midazolam and intravenous diazepam for the acute treatment of seizures in children.
MedLine Citation:
PMID:  23399743     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children.
METHODS: This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emergency department of a children's hospital. The primary outcome of this study was cessation of visible seizure activity within 5 minutes from administration of the first dosage. The second dosage was used in case the seizure remained uncontrolled 5 minutes after the first one.
FINDINGS: In the midazolam group, 22 (68.8%) patients were relieved from seizures in 10 minutes. Meanwhile, diazepam controlled the episodes of 42 (70%) patients within 10 minutes. The difference was, however, not statistically significant (P=0.9). The mean time required to control the convulsive episodes after administration of medications was not statistically significant (P=0.09). No significant side effects were observed in either group. Nevertheless, the risk of respiratory failure in intravenous diazepam is greater than in buccal midazolam.
CONCLUSION: Buccal midazolam is as effective as and safer than intravenous diazepam in control of seizures.
Seyed-Hassan Tonekaboni; Farhad Mahvelati Shamsabadi; Seyed-Saeed Anvari; Ali Mazrooei; Mohammad Ghofrani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of pediatrics     Volume:  22     ISSN:  2008-2142     ISO Abbreviation:  Iran J Pediatr     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-02-13     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  101274724     Medline TA:  Iran J Pediatr     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  -    
Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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