Document Detail


A comparison of bromocriptine & cabergoline on fertility outcome of hyperprolactinemic infertile women undergoing intrauterine insemination.
MedLine Citation:
PMID:  20516539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & OBJECTIVES: The aim of this study was to compare the effects of bromocriptine versus cabergoline on pregnancy in hyperprolactinaemic infertile women.
METHODS: A total of 183 infertile women with hyperprolactinemia undergoing intrauterine insemination (IUI) were randomly divided into two groups. Group A: 94 with bromocriptine and group B:89 with cabergoline. The efficacy and safety was evaluated on the basis of normalization of prolactin levels, normalization of menstrual cycle, disappearance of galactorrhea, occurrence of pregnancy and adverse effects with each of these medications.
RESULTS: The presence of galactorrhea and irregular menstruation were significantly lower in patients of group B than group A (P<0.001 and P=0.011, respectively) with a significant lower prevalence of side effects in cabergoline group. Pregnancy was significantly more achieved among the women with the treatment of cabergoline (82%) as compared to bromocriptine (56.4%) (P<0.001).
INTERPRETATION & CONCLUSION: Our results suggest that cabergoline treatment in infertile women with prolactinemia is more effective. It lowers prolactin with better tolerability and much more effective in the achievement of pregnancy.
Authors:
Shahdokht Motazedian; Lida Babakhani; Seyed-Mohammad Fereshtehnejad; Khatereh Mojthahedi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  131     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-09-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  670-4     Citation Subset:  IM    
Affiliation:
Shiraz University of Medical Sciences & Health Services, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bromocriptine / therapeutic use*
Ergolines / therapeutic use*
Female
Humans
Hyperprolactinemia / complications*
Infertility, Female / complications,  drug therapy*
Insemination, Artificial*
Chemical
Reg. No./Substance:
0/Ergolines; 25614-03-3/Bromocriptine; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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