Document Detail

A comparison of bispectral index and ARX-derived auditory evoked potential index in measuring the clinical interaction between ketamine and propofol anaesthesia.
MedLine Citation:
PMID:  12969037     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of a bolus (0.4 and continuous infusion (1 of ketamine on Bispectral Index (BIS) and A-Line(R) ARX Index (AAI) during propofol anaesthesia. We included 15 ASA I patients scheduled for general anaesthesia. Induction was performed by infusion of propofol at 100 ml.h-1 until loss of consciousness. Both BIS and AAI monitors responded appropriately at that time. The calculated effect site concentration of propofol at loss of consciousness was maintained by means of a computer controlled infusion system. A 'pseudo' steady-state effect site concentration was reached after 4 min. After 1 min of baseline measurements, ketamine was administered. BIS values increased from the 3rd to the 8th min after the administration of ketamine. The AAI showed no significant increase or decrease, but between-patient variability increased.
H E M Vereecke; M M R F Struys; E P Mortier
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  58     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-12     Completed Date:  2003-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  957-61     Citation Subset:  AIM; IM    
Department of Anaesthesia, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
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MeSH Terms
Adjuvants, Anesthesia / pharmacology
Anesthetics, Combined / pharmacology*
Anesthetics, Dissociative / pharmacology
Anesthetics, Intravenous / pharmacology
Drug Synergism
Electroencephalography / drug effects
Evoked Potentials, Auditory / drug effects*
Ketamine / pharmacology*
Middle Aged
Monitoring, Intraoperative / methods*
Propofol / pharmacology*
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Anesthetics, Combined; 0/Anesthetics, Dissociative; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 6740-88-1/Ketamine

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