| A comparison of bispectral index and ARX-derived auditory evoked potential index in measuring the clinical interaction between ketamine and propofol anaesthesia. | |
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MedLine Citation:
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PMID: 12969037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effects of a bolus (0.4 mg.kg-1) and continuous infusion (1 mg.kg-1.h-1) of ketamine on Bispectral Index (BIS) and A-Line(R) ARX Index (AAI) during propofol anaesthesia. We included 15 ASA I patients scheduled for general anaesthesia. Induction was performed by infusion of propofol at 100 ml.h-1 until loss of consciousness. Both BIS and AAI monitors responded appropriately at that time. The calculated effect site concentration of propofol at loss of consciousness was maintained by means of a computer controlled infusion system. A 'pseudo' steady-state effect site concentration was reached after 4 min. After 1 min of baseline measurements, ketamine was administered. BIS values increased from the 3rd to the 8th min after the administration of ketamine. The AAI showed no significant increase or decrease, but between-patient variability increased. |
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Authors:
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H E M Vereecke; M M R F Struys; E P Mortier |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Anaesthesia Volume: 58 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-12 Completed Date: 2003-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 957-61 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium. Hugo.Vereecke@softhome.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Anesthesia
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pharmacology Adolescent Adult Anesthetics, Combined / pharmacology* Anesthetics, Dissociative / pharmacology Anesthetics, Intravenous / pharmacology Drug Synergism Electroencephalography / drug effects Evoked Potentials, Auditory / drug effects* Humans Ketamine / pharmacology* Middle Aged Monitoring, Intraoperative / methods* Propofol / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Anesthesia; 0/Anesthetics, Combined; 0/Anesthetics, Dissociative; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 6740-88-1/Ketamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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