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A comparison between two imaging techniques for the diagnosis of subacute thyroiditis (de Quervain thyroiditis): brief communication.
MedLine Citation:
PMID:  20940543     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Subacute thyroiditis (SAT) or de Quervain thyroiditis is a relatively frequent and self-limited condition with a triphasic clinical course. Its symptoms can mimic other thyroid, upper respiratory, and ear infections. Thyroid ultrasonography (TUS), radioactive iodine uptake (RAIU), and thyroid scintigraphy (TS) may be used for differential diagnosis. To assess and compare the diagnostic value of thyroid TUS and TS in patients on the first phase of a clinically diagnosed SAT.
MATERIAL AND METHODS: Twenty-two patients (18 women and 4 men, age, 37.2 ± 9.83 years) with clinical diagnosis of SAT were prospectively studied. Thyroid stimulating hormone, T3, free T4, antithyroperoxidase antibodies, thyroglobulin, polymerase chain reaction, complete blood count and differential, TUS, TS, and RAIU at 2 and 24 hours were performed.
RESULTS: All patients were on thyrotoxic phase with a thyroid stimulating hormone mean of 0.03 ± 0.030 mU/L (range: 0.005-0.13); antithyroperoxidase antibodies were positive in 3 patients (≥75 UI/mL); thyroglobulin was elevated in 16 patients (≥55 ng/mL). RAIU at 2 hours was 1.94% ± 0.85% (range: 1%-4%), and at 24 hours, 0.98% ± 1.24% (range: 0.10%-5%). TS showed low uptake in all patients. On TUS, only 8 patients were compatible with SAT. In 13 patients, TUS was consistent with goiter, diffuse type in 8, multinodular in 5, and normal in 1 patient.
CONCLUSION: Low thyroid scan uptake with I-131 at 2 hours (<4%) and 24 hours (<5%), and poor thyroid visualization on TS seem to be more prevalent than focal distortion and heterogeneity in TUS in thyrotoxic phase of SAT.
Patricio González Espinoza; Claudio Liberman Guendelman; Lidya Nieves Quevedo Limón; Rodrigo Jaimovich Fernández
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  35     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  862-4     Citation Subset:  IM    
Nuclear Medicine Section, Department of Medicine, Clinical Hospital, University of Chile, Santiago, Chile.
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MeSH Terms
Diagnosis, Differential
Diagnostic Imaging / methods*
Middle Aged
Retrospective Studies
Thyroid Gland / radionuclide imaging,  ultrasonography
Thyroiditis, Subacute / radionuclide imaging*,  ultrasonography*
Young Adult

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