Document Detail

A comparison between sodium nitroprusside and trimetaphan-induced hypotension.
MedLine Citation:
PMID:  7457069     Owner:  NLM     Status:  MEDLINE    
Hypotension induced with nitroprusside is compared with the same degree of hypotension produced by trimetaphan in terms of cerebral perfusion, oxygenation and brain electrical activity. It is concluded that in all these respects nitroprusside has advantages over trimetaphan. On the other hand, nitroprusside increases intracranial pressure whilst trimetaphan does not. Both these drugs have a place in hypotension for neurosurgery.
D G McDowall
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Belgica     Volume:  31 Suppl     ISSN:  0001-5164     ISO Abbreviation:  Acta Anaesthesiol Belg     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421022     Medline TA:  Acta Anaesthesiol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  73-5     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism,  surgery*
Cerebrovascular Circulation / drug effects
Ferricyanides / pharmacology*
Hypotension, Controlled*
Intracranial Pressure / drug effects
Nitroprusside / pharmacology*
Trimethaphan / pharmacology*
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside; 7187-66-8/Trimethaphan; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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