Document Detail

A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism.
MedLine Citation:
PMID:  19337013     Owner:  NLM     Status:  MEDLINE    
To investigate the clinical efficacy and safety of the finasteride (5 mg/day) plus flutamide (125 mg/day) combination therapy in unselected women with hirsutism, 44 women were involved in the study. The effects of such combination treatment have not been reported previously. The patients were assigned to 3 treatment groups: 14 patients (group 1) were treated with finasteride (5 mg per day), 16 patients (group 2) were treated with flutamide (125 mg per day), and 14 patients (group 3) were treated with finasteride (5 mg per day) plus flutamide (125 mg per day) for 12 months. Serum FSH, LH, estradiol, total testosterone, free testosterone, androstenedione, DHEAS, and SHBG were obtained. Hirsutism score was measured before and after treatment. Blood chemistry and side effects were evaluated during the study. The reductions in hirsutism score (% of the baseline) at 6 months were as follows: 24% for group 1, 35% for group 2, and 33% for group 3. Combination therapy resulted in (49%) similar improvement to flutamide alone (45%), but significantly (p<0.05) more efficacious improvement in hirsutism when compared to finasteride (32%) after 12 months of treatment. In conclusion, flutamide is more effective than finasteride and the combination of these two drugs is not better than flutamide alone, but better than finasteride in hirsute women.
K Unluhizarci; D Ozel; F Tanriverdi; Z Karaca; F Kelestimur
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  32     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
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MeSH Terms
Androgen Antagonists / therapeutic use*
Drug Therapy, Combination
Finasteride / therapeutic use*
Flutamide / therapeutic use*
Hirsutism / drug therapy*
Prospective Studies
Reg. No./Substance:
0/Androgen Antagonists; 13311-84-7/Flutamide; 98319-26-7/Finasteride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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