Document Detail

A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans.
MedLine Citation:
PMID:  10960017     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been shown that clinical improvement of intrabony periodontal defects can be achieved with the use of enamel matrix proteins (EMPs) or by grafting with bovine porous bone mineral (BPBM). There is no report on the potential synergistic effect of EMPs and BPBM in periodontal regenerative therapy. The purpose of this study was to compare the clinical effectiveness of EMPs used alone or in combination with BPBM in the treatment of periodontal intrabony defects in humans. METHODS: Twenty-one paired intrabony defects were surgically treated using a split-mouth design. Intrabony defects were treated either with enamel matrix proteins (EMP group) or with enamel matrix proteins combined with bovine porous bone mineral (EMP/BPBM group). Re-entry surgeries were performed at 6 months. RESULTS: Preoperative probing depths, attachment levels, and transoperative bone measurements were similar for the EMP and EMP/BPBM groups. Postsurgical measurements taken at 6 months revealed a significantly greater reduction in probing depth in the EMP/BPBM group (3.43 +/- 1.32 mm on buccal sites and 3.36 +/- 1.35 mm on lingual sites) when compared to the EMP group (1.91 +/- 1.42 mm on buccal sites and 1.85 +/- 1.38 mm on lingual sites). The EMP/BPBM group also presented with significantly more attachment gain (3.13 +/- 1.41 mm on buccal sites and 3.11 +/- 1.39 mm on lingual sites) than the EMP group (1.72 +/- 1.33 mm on buccal sites and 1.75 +/- 1.37 mm on lingual sites). Surgical re-entry of the treated defects revealed a significantly greater amount of defect fill in favor of the EMP/BPBM group (3.82 +/- 1.43 mm on buccal sites and 3.74 +/- 1.38 mm on lingual sites) as compared to the EMP group (1.33 +/1.17 mm on buccal sites and 1.41 +/- 1.19 mm on lingual sites). CONCLUSIONS: The results of this study indicate that BPBM has the ability to augment the effects of EMPs in reducing probing depth, improving clinical attachment levels, and promoting defect fill when compared to presurgical levels.
V Lekovic; P M Camargo; M Weinlaender; M Nedic; Z Aleksic; E B Kenney
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of periodontology     Volume:  71     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-18     Completed Date:  2000-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1110-6     Citation Subset:  D; IM    
University of California Los Angeles, School of Dentistry, 90095, USA.
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MeSH Terms
Alveolar Bone Loss / surgery*
Bone Matrix / transplantation*
Bone Regeneration*
Bone Transplantation / methods*
Combined Modality Therapy
Dental Enamel Proteins / therapeutic use*
Dental Plaque Index
Periodontal Attachment Loss / surgery
Periodontal Index
Treatment Outcome
Reg. No./Substance:
0/Dental Enamel Proteins; 0/enamel matrix proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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