Document Detail

The comparison between the efficacy of high dose acyclovir and erythromycin on the period and signs of pitiriasis rosea.
MedLine Citation:
PMID:  21063515     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Pityriasis Rosea (PR) is an acute inflammatory and self-limiting skin disorder, sometimes with troublesome symptoms. To date, there are few treatments available for this disorder.
AIM: Compare the traditional treatment with erythromycin to a newly introduced antiviral treatment acyclovir for PR.
MATERIALS AND METHODS: Patients with clinically confirmed diagnosis of PR, matching our exclusion criteria, were enrolled. They were randomized in two groups that received high-dose oral acyclovir or erythromycin. The participants were evaluated two, four, and eight weeks after commencement of the study and followed for one year.
RESULTS: A total of 30 patients including 15 males and 15 females completed the study. After eight weeks, 13 patients in the acyclovir group experienced complete response, while in the erythromycin group only six patients had complete response (P < 0.05). Also, patients in the acyclovir group experienced faster resolution of pruritus in comparison with the erythromycin group (not significant). No adverse drug reaction was detected in both groups.
CONCLUSION: It seemed that a high-dose of oral acyclovir was a safe and effective therapy for PR, although this remained to be confirmed in larger studies.
Amirhooshang Ehsani; Nafiseh Esmaily; Pedram Noormohammadpour; Siavash Toosi; Alireza Hosseinpour; Mahbobeh Hosseini; Shima Sayanjali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of dermatology     Volume:  55     ISSN:  1998-3611     ISO Abbreviation:  Indian J Dermatol     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2010-11-10     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370750     Medline TA:  Indian J Dermatol     Country:  India    
Other Details:
Languages:  eng     Pagination:  246-8     Citation Subset:  -    
Department of Dermatology, Tehran University of Medical Sciences, Razi Hospital Iran.
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