Document Detail

A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents.
MedLine Citation:
PMID:  7662164     Owner:  NLM     Status:  MEDLINE    
When low doses of insulin are infused directly into the third ventricle, rats reduce their food intake and lose weight. To determine whether these effects could be due to malaise induced by the treatment, the effects of intraventricular insulin were compared to the effects of the emetic agent lithium chloride to condition a taste aversion, to stimulate oxytocin secretion, and to reduce sodium appetite in response to furosemide treatment. For all three of these measures, lithium chloride treatment had a predictable effect compared to controls. Specifically, lithium caused a significant taste aversion, elevated plasma oxytocin, and attenuated sodium appetite. However, lithium did not produce a significant change in food intake or body weight. On the other hand, intraventricular insulin treatment did cause a significant reduction in body weight yet had no effect on these indices of malaise in the rat. These data are consistent with the hypothesis that intraventricular insulin does not reduce food intake and body weight by producing malaise but rather serves as a negative feedback signal of body adiposity to the central nervous system.
M Chavez; R J Seeley; S C Woods
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  109     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-10     Completed Date:  1995-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  IM    
Department of Psychology, University of Washington, Seattle 98195, USA.
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MeSH Terms
Appetite / drug effects
Avoidance Learning / drug effects
Body Weight / drug effects*
Dose-Response Relationship, Drug
Eating / drug effects*
Injections, Intraperitoneal
Injections, Intraventricular
Insulin / pharmacology*
Lithium Chloride / pharmacology*
Oxytocin / blood
Taste / drug effects
Viscera / innervation
Water-Electrolyte Balance / drug effects
Grant Support
Reg. No./Substance:
11061-68-0/Insulin; 50-56-6/Oxytocin; 7447-41-8/Lithium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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