Document Detail

A comparison between TNM and TANIS stage grouping for predicting prognosis of oral and oropharyngeal cancer.
MedLine Citation:
PMID:  9663573     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The 1987 TNM classification system modified some T and N definition but it did not change stage grouping. Consequently it has not improved the prognostic validity of the advanced stage groups. In 1993, a new stage grouping was purposed, TANIS, that seems to have a higher correlation with survival. In this report, the TNM classification and TANIS system were compared to evaluate this prognostic ability. PATIENTS AND METHODS: Data from 164 patients affected by primary cancers of oropharynx or oral cavity were analyzed by means of Kaplan-Meier and Cox regression analysis. RESULTS: The crude survival rate at 5 years was 43.9%. Both systems showed a significant correlation with the survival rate by means of Cox regression analysis. TANIS subcategories were correlated to the mortality rate in the stage IV patients. TANIS resulted a better predictor of mortality when compared with TNM. CONCLUSION: The TANIS system was able to separate the TNM stage IV patients into prognostic groups, yielding more information with respect to TNM for such a category of patients. When a comparison between TNM and TANIS was performed, it was observed that TANIS had a higher correlation with survival rate, whereas TNM did not add any information in defining the survival function.
F Carinci; S Pelucchi; A Farina; C Calearo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  56     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-28     Completed Date:  1998-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-6; discussion 836-7     Citation Subset:  AIM; D; IM    
University of Ferrara, Italy.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Carcinoma, Squamous Cell / classification,  pathology*
Evaluation Studies as Topic
Likelihood Functions
Middle Aged
Mouth Neoplasms / classification,  pathology*
Neoplasm Staging / methods*
Oropharyngeal Neoplasms / classification,  pathology*
Proportional Hazards Models
Reproducibility of Results
Survival Rate
Comment In:
J Oral Maxillofac Surg. 1999 Mar;57(3):356   [PMID:  10077212 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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