| A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation. | |
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MedLine Citation:
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PMID: 3499925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fourteen patients with established atrial fibrillation (longer than three months) that was refractory to treatment were studied to compare the clinical and electrophysiological effects of amiodarone and bepridil. All patients initially received bepridil for three weeks (200-600 mg/day), followed by amiodarone for two to three months (100-400 mg/day). Bepridil seemed to be slightly more effective than amiodarone in converting the fibrillation to sinus rhythm (nine of fourteen compared with four of ten). The ventricular response in atrial fibrillation was equally well controlled by bepridil and amiodarone, both at rest and during exercise. Bepridil was associated with the development of ventricular arrhythmias in eight of fourteen patients; two had torsade de pointes, which in one degenerated into fatal ventricular fibrillation. These arrhythmias seemed to be associated with bepridil induced prolongation of the QTc interval. No ventricular arrhythmias were seen during amiodarone treatment. Although bepridil seems to be an effective antiarrhythmic agent for the management of atrial fibrillation, its arrhythmogenic actions make it unsuitable for this purpose. |
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Authors:
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M S Perelman; W J McKenna; E Rowland; D M Krikler |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British heart journal Volume: 58 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-01-21 Completed Date: 1988-01-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 339-44 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Disease, Royal Postgraduate Medical School, Hammersmith Hospital, London. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / therapeutic use* Anti-Arrhythmia Agents / therapeutic use* Arrhythmias, Cardiac / chemically induced Atrial Fibrillation / drug therapy*, physiopathology Bepridil Chronic Disease Electrocardiography Female Heart Rate / drug effects Heart Ventricles Humans Male Middle Aged Pyrrolidines / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Pyrrolidines; 1951-25-3/Amiodarone; 64706-54-3/Bepridil |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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