| A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants. | |
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MedLine Citation:
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PMID: 20522170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive. METHODS: Diabetes Prevention Trial-Type 1 (DPT-1) participants were screened for islet cell autoantibodies, whereas TrialNet Natural History Study (TNNHS) participants were screened for biochemical autoantibodies. In both studies, those determined to be autoantibody positive underwent baseline oral glucose tolerance tests (OGTTs) in which glucose and C-peptide were measured. RESULTS: The percentage of those with an OGTT in the diabetic range was higher among the DPT-1 participants (10.0% of 956 vs. 6.4% of 645, p < 0.01). In a logistic regression analysis with adjustments for age and gender, the difference persisted (p < 0.01). Among those in the non-diabetic range (n = 860 for DPT-1 and n = 604 for the TNNHS), glucose levels were similar at all time points, except for higher fasting glucose levels in the TNNHS participants (p < 0.001). There was a higher percentage of impaired fasting glucose (IFG) in the TNNHS participants (10.9 vs. 6.7%, p < 0.01); however, with adjustments for age and gender, there was no longer a significant difference. There was no significant difference in the percentages with impaired glucose tolerance. C-peptide levels were much lower in the DPT-1 cohort at all OGTT time points (p < 0.001 for all). DISCUSSION: Differing criteria for autoantibody screening can result in marked differences in the baseline metabolic profiles of prospective participants of T1D prevention trials. |
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Authors:
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Jay M Sosenko; Jeffrey Mahon; Lisa Rafkin; John M Lachin; Heidi Krause-Steinrauf; Jeffrey P Krischer; David Cuthbertson; Jerry P Palmer; Clinton Thompson; Carla J Greenbaum; Jay S Skyler; |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric diabetes Volume: 12 ISSN: 1399-5448 ISO Abbreviation: Pediatr Diabetes Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-28 Completed Date: 2011-06-23 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: Denmark |
Other Details:
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Languages: eng Pagination: 85-90 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Division of Endocrinology, University of Miami, Miami, FL, USA. jsosenko@med.miami.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autoantibodies / analysis*, metabolism Basal Metabolism / physiology* Biological Markers / analysis, metabolism Child Child, Preschool Clinical Trials as Topic / methods* Cohort Studies Diabetes Mellitus, Type 1 / diagnosis, metabolism, prevention & control* Female Humans Infant Male Mass Screening / methods Metabolome* Middle Aged Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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U01 DK061041-06/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Biological Markers; 0/islet cell antibody |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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