| A comparison of aztreonam and ceftazidime in the treatment of respiratory infections in adults with cystic fibrosis. | |
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MedLine Citation:
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PMID: 1641599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A randomised double blind 2-week trial of monotherapy with ceftazidime and aztreonam was completed in 22 adults with cystic fibrosis. 26 courses of treatment were initiated and 22 courses were completed. Within groups, both ceftazidime and aztreonam demonstrated a significant improvement in FEV1 at 2 weeks (ceftazidime p less than 0.05; aztreonam p less than 0.01) and a decline in sputum weight at 2 weeks (ceftazidime p less than 0.05; aztreonam p less than 0.05). Between groups, for spirometry and sputum weight the only change was a slower decline in FEV1 in the aztreonam group at 42 days (p less than 0.05). |
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Authors:
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B Salh; D Bilton; M Dodd; J Abbot; K Webb |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of infectious diseases Volume: 24 ISSN: 0036-5548 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-09-01 Completed Date: 1992-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 215-8 Citation Subset: IM |
Affiliation:
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Adult Regional Cystic Fibrosis Unit, Monsall Hospital, Manchester, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aztreonam / therapeutic use* Ceftazidime / therapeutic use* Cystic Fibrosis / complications* Double-Blind Method Female Forced Expiratory Volume Humans Male Pseudomonas aeruginosa / isolation & purification, ultrastructure Respiratory Tract Infections / drug therapy*, etiology Sputum / microbiology |
| Chemical | |
Reg. No./Substance:
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78110-38-0/Aztreonam; 78439-06-2/Ceftazidime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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