Document Detail


A comparison of antihypertensive effects of atenolol and propranolol in the spontaneously hypertensive, DOCA/saline hypertensive and renal hypertensive rats.
MedLine Citation:
PMID:  7098145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antihypertensive effects of a long-term oral regimen of atenolol were studied in SHR, DOCA/saline hypertensive and renal hypertensive rats (one kidney, one clip) in comparison with the effects of propranolol. Both the beta-blockers prevented the development of hypertension in SHR but did not affect that in DOCA/saline and renal hypertensive rats. Both of the beta-blockers produced no acute hypotensive effects on the established DOCA/saline and renal hypertension of the rat, although they produced a decrease in the heart rate.
Authors:
K Takeda; Y Nakagawa; W P Chin; S Imai
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  32     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  283-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / therapeutic use*
Atenolol / therapeutic use*
Desoxycorticosterone
Hypertension / chemically induced,  drug therapy*
Hypertension, Renal / drug therapy*
Propanolamines / therapeutic use*
Propranolol / therapeutic use*
Rats
Sodium Chloride
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Propanolamines; 29122-68-7/Atenolol; 525-66-6/Propranolol; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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