Document Detail


A comparison of anti-type II collagen antibody titres and isotype profiles in pregnant and virgin DBA/1 mice with collagen-induced arthritis.
MedLine Citation:
PMID:  2760906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to discover whether changes in the nature of the humoral response to type II collagen occur during pregnancy we compared, by enzyme-linked immunosorbent assay (ELISA), the anti-type II collagen antibody titres and isotype profiles of pregnant and virgin DBA/1 mice immunized with type II collagen. Significant reductions in the mean clinical scores and anti-collagen antibody titres were observed during late pregnancy. Titres of all of the anti-collagen isotypes tended to be lower in pregnant than non-pregnant mice, although only in the case of IgG3 was there a significant difference between the two groups. We conclude that while pregnancy may cause changes to the isotype distribution of anti-collagen antibodies it is not possible on the basis of this study to relate such changes to the remission of arthritis observed during pregnancy.
Authors:
R O Williams; A Whyte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  15     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-20     Completed Date:  1989-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-39     Citation Subset:  IM    
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthritis / chemically induced,  immunology*
Collagen / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Immunization
Immunoglobulin Isotypes / analysis
Mice
Mice, Inbred DBA
Pregnancy
Pregnancy Complications / immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulin Isotypes; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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