Document Detail


A comparison of ketamine/xylazine and ketamine/xylazine/acepromazine anesthesia in the rabbit.
MedLine Citation:
PMID:  2166867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parenteral anesthetic combinations such as ketamine and xylazine have become the agents of choice for anesthesia in the rabbit, because they are effective, easily administered and inexpensive. A number of recent reports have recommended including acepromazine in this combination, but a critical evaluation of this combination in the rabbit has not been reported. Five adult New Zealand white rabbits were anesthetized intramuscularly with ketamine (35 mg/kg) and xylazine (5 mg/kg) with or without acepromazine (0.75 mg/kg). The study was conducted in a double blind fashion, where each rabbit was administered both combinations at a minimum of 7 day intervals. Physiologic parameters were evaluated including heart rate, respiratory rate, central arterial blood pressure, pedal, palpebral and postural reflex activity. The duration of general anesthesia, estimated by the time elapsed between the loss and return of the palpebral reflex, was greater (means = 99 +/- 20 minutes) when acepromazine was employed in the combination compared to (means = 77 +/- 5 minutes) when ketamine/xylazine were used alone. Mean central arterial blood pressure reached a lower level when acepromazine was utilized (means = 46 +/- 8 mm/Hg) than when it was not (means = 57 +/- 12 mm/Hg.). The addition of acepromazine in a ketamine/xylazine combination resulted in a 28% longer period of anesthesia, a 19% lower mean central arterial blood pressure and a 32% longer recovery of postural reflexes. The ketamine/xylazine/acepromazine combination is a useful regimen for normovolemic animals when anesthetic duration greater than that produced by ketamine/xylazine alone is required.
Authors:
N S Lipman; R P Marini; S E Erdman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory animal science     Volume:  40     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-09-18     Completed Date:  1990-09-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Affiliation:
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
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MeSH Terms
Descriptor/Qualifier:
Acepromazine*
Anesthesia / veterinary*
Animals
Blood Pressure Determination / veterinary
Double-Blind Method
Drug Interactions
Ketamine*
Rabbits*
Specific Pathogen-Free Organisms
Thiazines*
Time Factors
Xylazine*
Grant Support
ID/Acronym/Agency:
RR01046/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Thiazines; 61-00-7/Acepromazine; 6740-88-1/Ketamine; 7361-61-7/Xylazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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