Document Detail

A comparison of analysis of variance and correlation methods for investigating cognitive development with functional magnetic resonance imaging.
MedLine Citation:
PMID:  16925474     Owner:  NLM     Status:  MEDLINE    
Statistical approaches used in functional magnetic resonance imaging (fMRI) to study cognitive development are varied and evolving. Two approaches have generally been used. These are between-group end-point analysis of variance (ANOVA) and age-related regression. Differences in these 2 approaches could produce different results when applied to a single data set. Event-related fMRI data from a group of typically developing participants (n = 95; age range = 7-35 years) performing controlled lexical processing tasks were analyzed using both methods. Results from the 2 approaches showed significant overlap, but also noteworthy differences. The results suggest that for regions showing age-related changes, correlation was relatively more sensitive to more linear changes whereas ANOVA was relatively more sensitive to less-linear changes. These findings suggest that full characterization of developmental dynamics will require converging methodologies.
Damien A Fair; Timothy T Brown; Steven E Petersen; Bradley L Schlaggar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental neuropsychology     Volume:  30     ISSN:  8756-5641     ISO Abbreviation:  Dev Neuropsychol     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-23     Completed Date:  2006-10-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8702038     Medline TA:  Dev Neuropsychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-46     Citation Subset:  IM    
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
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MeSH Terms
Aging / physiology*
Analysis of Variance
Brain / blood supply*,  growth & development,  physiology
Brain Mapping*
Cognition / physiology*
Functional Laterality / physiology
Image Processing, Computer-Assisted / methods
Linear Models
Magnetic Resonance Imaging*
Oxygen / blood
Grant Support
Reg. No./Substance:

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