Document Detail

A comparison of ambulatory blood pressure patterns across populations.
MedLine Citation:
PMID:  12409885     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Black individuals are characterized by a blunted nocturnal decline (i.e. dipping) in blood pressure compared with whites. The resulting increase in cardiovascular load has been hypothesized to contribute to ethnic differences in hypertension and its sequelae. OBJECTIVE: To examine data from two different locations and determine factors related to ethnic differences in ambulatory blood pressure pattern. METHODS: Ambulatory blood pressure recordings were performed on 300 youths from Memphis, Tennessee and 195 youths from Augusta, Georgia, USA. Stepwise regressions were performed to determine the factors associated with daytime and night-time blood pressure and the nocturnal decline in blood pressure. The factors examined were recording location, ethnicity, gender, age, height, weight and genetic predisposition. RESULTS: Significant factors in the model for the nocturnal decline in systolic blood pressure included location (R(2) = 0.031, P < 0.001), followed by ethnicity (R(2) change = 0.015, P < 0.006) and height (R(2) change = 0.009,P < 0.03). Significant factors in the model for the nocturnal decline in diastolic blood pressure included location ( R(2) = 0.176, P < 0.001), followed by ethnicity ( R(2) change = 0.016, P < 0.002) and height (R(2) change = 0.02, P < 0.001). The nocturnal decline was greater in the Augusta subjects because of higher daytime systolic (P < 0.002) and diastolic (P < 0.001) blood pressure. Weight contributed significantly to the models for resting blood pressure and daytime blood pressure. Gender was the only variable that contributed to the model for resting systolic blood pressure. CONCLUSIONS: Both genetic and environmental factors contribute to individual differences in ambulatory blood pressure patterns. Much of the variance of ambulatory blood pressure levels and patterns remains, however, unexplained.
Gregory A Harshfield; Martha E Wilson; Frank A Treiber; Bruce S Alpert
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  7     ISSN:  1359-5237     ISO Abbreviation:  Blood Press Monit     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2003-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Department of Pediatrics and Georgia Prevention Institute, Medical College of Georgia, Augusta, 30912-4534, USA.
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MeSH Terms
African Americans*
Blood Pressure*
Blood Pressure Monitoring, Ambulatory / statistics & numerical data*
Cardiovascular Diseases / ethnology,  etiology
Circadian Rhythm
Ethnic Groups
Hypertension / ethnology,  etiology
Regression Analysis
Risk Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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