Document Detail

A comparison of Tl-201, Tc-99m sestamibi, and Tc-99m tetrofosmin myocardial perfusion scintigraphy in patients with mild to moderate coronary stenosis.
MedLine Citation:
PMID:  16919572     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thallium 201, technetium 99m sestamibi (MIBI), and Tc-99m tetrofosmin differ in their myocardial uptake characteristics. This may make the technetium tracers less sensitive for detecting mild to moderate coronary stenosis. METHODS AND RESULTS: We identified 163 patients with angiographic mild to moderate stenosis (50%-89%) and coexistent severe disease (88/163 patients) from a previous study of patients who received either thallium, MIBI, or tetrofosmin for myocardial perfusion scintigraphy. Summed segmental uptake scores were used to assess myocardial perfusion of territories supplied by the mildly to moderately stenotic vessels. Mean (+/- SD) summed stress uptake scores in the left anterior descending artery territory were 21.4 +/- 3.8, 21.6 +/- 4.2, and 22.1 +/- 2.3 for thallium, MIBI, and tetrofosmin, respectively (P = .7); mean summed difference uptake scores were 1.2 +/- 1.8, 1.1 +/- 1.9, and 1.0 +/- 1.1, respectively (P = .8). In the non-left anterior descending artery territory, mean summed stress uptake scores were 32.5 +/- 6.3, 34.0 +/- 6.3, and 34.5 +/- 4.7 for thallium, MIBI, and tetrofosmin, respectively (P = .4), whereas mean summed difference scores were 1.9 +/- 2.6, 1.7 +/- 2.2, and 1.7 +/- 2.3, respectively (P = .9). CONCLUSION: There were no significant differences between the tracers for the summed uptake scores. This suggests that the 3 tracers are comparable in clinical practice for assessing the extent and severity of perfusion abnormalities arising from mild to moderate coronary artery stenosis, especially in the presence of coexistent severe disease.
Eliana Reyes; Chee Y Loong; Mark Harbinson; Shelley Rahman; Elizabeth Prvulovich; Peter J Ell; Constantinos Anagnostopoulos; S Richard Underwood
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  13     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-94     Citation Subset:  IM    
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
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MeSH Terms
Coronary Stenosis / radionuclide imaging*
Middle Aged
Organophosphorus Compounds / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Severity of Illness Index
Technetium Tc 99m Sestamibi / diagnostic use*
Thallium / diagnostic use*
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 109581-73-9/Technetium Tc 99m Sestamibi; 7440-28-0/Thallium; 7791-12-0/thallium chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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