Document Detail

A comparison of 8% and 12% sevoflurane for inhalation induction in adults.
MedLine Citation:
PMID:  14687093     Owner:  NLM     Status:  MEDLINE    
Sevoflurane is a non-pungent volatile anaesthetic agent with a low blood-gas solubility coefficient. It has been studied in concentrations of up to 8% for induction of anaesthesia. Previous work has suggested that there may be a ceiling effect with increasing concentration of sevoflurane above 6%, but there are no published studies using 12% sevoflurane. This study compared 8 and 12% sevoflurane to induce anaesthesia in adults. Sevoflurane was administered using two adapted datum vaporisers with the interlock removed. Induction with 12% sevoflurane compared to 8% sevoflurane produced a significant decrease in the time to achieve central pupils, corresponding to surgical anaesthesia and the third part of Guedel's stage 3 of anaesthesia (mean time (SD) 201 s (81) and 247 s (39), respectively, p < 0.05). Twelve-percent sevoflurane produced a similar stable cardiovascular profile to 8% sevoflurane, and there was no increase in respiratory complications.
N Goodwin; A E Campbell; J E Hall; S Plummer; M Harmer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  59     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  AIM; IM    
Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XW, UK.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage*,  pharmacology
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Double-Blind Method
Electroencephalography / drug effects
Heart Rate / drug effects
Methyl Ethers / administration & dosage*,  pharmacology
Middle Aged
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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