Document Detail

A comparative trial of single dose chemotherapy in paucibacillary leprosy patients with two to three skin lesions.
MedLine Citation:
PMID:  11579649     Owner:  NLM     Status:  MEDLINE    
A multicentric, double-blind, controlled, clinical trial was carried out to compare the efficacy of a combination of rifampicin 600 mg plus ofloxacin 400 mg plus minocycline 100 mg (ROM) administered as single dose with that of standard WHO/MDT/PB six months regimen. The study subjects were 236 previously untreated, smear-negative patients, without nerve trunk involvement and having only two or three skin lesions. Randomization was done on individual patient basis. Results were analyzed for mean clinical score for improvement, marked clinical improvement and complete clinical cure at the time of release from treatment and at 12 months and 18 months of follow-up. Clinical improvement was seen in most patients in both regimens. Marked improvement (i.e., more than 90% reduction in clinical score) at 18 months was seen in 46.2% and 53.4% of the patients treated with ROM and standard regimens, respectively. But, significant difference in favour of standard PB regimen was seen in patients with three skin lesions and in patients in whom more than one body part was affected. Reversal reaction and adverse drug reactions were minimal in both groups.
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of leprosy     Volume:  73     ISSN:  0254-9395     ISO Abbreviation:  Indian J Lepr     Publication Date:    2001 Apr-Jun
Date Detail:
Created Date:  2001-10-02     Completed Date:  2002-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409173     Medline TA:  Indian J Lepr     Country:  India    
Other Details:
Languages:  eng     Pagination:  131-43     Citation Subset:  IM    
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MeSH Terms
Double-Blind Method
Drug Therapy, Combination
Leprostatic Agents / administration & dosage,  therapeutic use*
Leprosy / drug therapy*
Minocycline / administration & dosage,  therapeutic use*
Ofloxacin / administration & dosage,  therapeutic use*
Rifampin / administration & dosage,  therapeutic use*
Skin / pathology
Treatment Outcome
Reg. No./Substance:
0/Leprostatic Agents; 10118-90-8/Minocycline; 13292-46-1/Rifampin; 82419-36-1/Ofloxacin
Comment In:
Indian J Lepr. 2001 Oct-Dec;73(4):364-6; author reply 366-7   [PMID:  11898472 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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