Document Detail

A comparative trial of cholestyramine and loperamide for acute diarrhoea in infants treated as outpatients.
MedLine Citation:
PMID:  3901661     Owner:  NLM     Status:  MEDLINE    
Infants aged 4 to 36 months with acute diarrhoea (rotavirus 66%) were treated as outpatients with oral fluids and a rapid return to full feedings. In addition, the infants were randomized to receive for 3 days either cholestyramine 2 g twice daily (N = 10), an equivalent placebo 2 g twice daily (N = 15), or loperamide 0.10 mg/kg divided in three doses (N = 16). The duration of watery diarrhoea from the beginning of treatment was 0.9 +/- 1.0 days in the cholestyramine group, 2.5 +/- 1.3 days in the loperamide group, and 3.3 +/- 1.6 days in the placebo group (p less than 0.001 cholestyramine vs. placebo, p less than 0.005 cholestyramine vs. loperamide). The infants receiving cholestyramine also had a better weight gain than those receiving the placebo, and their metabolic acidosis was corrected sooner. There was no hyperchloraemia associated with the cholestyramine treatment. It is concluded that cholestyramine 2 g twice daily for 3 days can be safely used to shorten the course of acute diarrhoea. The use of loperamide in acute infantile diarrhoea does not appear justified.
T Vesikari; E Isolauri
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  74     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-11-07     Completed Date:  1985-11-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Ambulatory Care
Child, Preschool
Cholestyramine Resin / therapeutic use*
Clinical Trials as Topic
Diarrhea / drug therapy*
Diarrhea, Infantile / drug therapy*
Fluid Therapy
Loperamide / therapeutic use*
Piperidines / therapeutic use*
Water-Electrolyte Balance / drug effects
Reg. No./Substance:
0/Piperidines; 11041-12-6/Cholestyramine Resin; 53179-11-6/Loperamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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