| A comparative trial of cholestyramine and loperamide for acute diarrhoea in infants treated as outpatients. | |
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MedLine Citation:
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PMID: 3901661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infants aged 4 to 36 months with acute diarrhoea (rotavirus 66%) were treated as outpatients with oral fluids and a rapid return to full feedings. In addition, the infants were randomized to receive for 3 days either cholestyramine 2 g twice daily (N = 10), an equivalent placebo 2 g twice daily (N = 15), or loperamide 0.10 mg/kg divided in three doses (N = 16). The duration of watery diarrhoea from the beginning of treatment was 0.9 +/- 1.0 days in the cholestyramine group, 2.5 +/- 1.3 days in the loperamide group, and 3.3 +/- 1.6 days in the placebo group (p less than 0.001 cholestyramine vs. placebo, p less than 0.005 cholestyramine vs. loperamide). The infants receiving cholestyramine also had a better weight gain than those receiving the placebo, and their metabolic acidosis was corrected sooner. There was no hyperchloraemia associated with the cholestyramine treatment. It is concluded that cholestyramine 2 g twice daily for 3 days can be safely used to shorten the course of acute diarrhoea. The use of loperamide in acute infantile diarrhoea does not appear justified. |
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Authors:
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T Vesikari; E Isolauri |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 74 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-11-07 Completed Date: 1985-11-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 650-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Ambulatory Care Child, Preschool Cholestyramine Resin / therapeutic use* Clinical Trials as Topic Diarrhea / drug therapy* Diarrhea, Infantile / drug therapy* Fluid Therapy Humans Infant Loperamide / therapeutic use* Piperidines / therapeutic use* Water-Electrolyte Balance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 11041-12-6/Cholestyramine Resin; 53179-11-6/Loperamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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