Document Detail


The comparative toxicology of 4-chloro-2-methylphenoxyacetic acid and its plant metabolite 4-chloro-2-carboxyphenoxyacetic acid in rats.
MedLine Citation:
PMID:  15896442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
4-Chloro-2-carboxyphenoxyacetic acid (CCPA) residues have occasionally been observed in crops treated with 4-chloro-2-methylphenoxyacetic acid (MCPA). The oral toxicity of MCPA and CCPA was compared in a 4-week rat study at a dietary concentration of 2000 ppm. CCPA was also given at 12,000 ppm (equivalent to 1g/kg bodyweight/day). MCPA at 2000 ppm caused reduced food consumption and body weight gain and increased water consumption in females only. Changes in clinical chemistry confirmed the liver as a target organ. Increased serum creatinine and urobilinogen, degenerated transitional epithelial cells in the urine showed that the kidney was also affected. Response to CCPA was confined to the 12,000 ppm dose. The target organs were liver and kidney as for MCPA. Microscopic examination revealed an increased severity of basophilic tubules and calcification at the outer/inner medulla transition in the kidneys. The results demonstrate that CCPA is less toxic than MCPA, that CCPA has no different toxicological end points when compared to MCPA, and that any risks associated with consumption of CCPA will not be underestimated if the CCPA residue is treated as if it were parent MCPA. Based on the MCPA-CCPA comparison, criteria for read across and minimal information requirements are proposed.
Authors:
B van Ravenzwaay; W Mellert; K Deckardt; K Küttler
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-02-24
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  42     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2006-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Affiliation:
BASF Aktiengesellschaft, Experimental Toxicology and Ecology, Z 470, D-67056 Ludwigshafen, Germany. bennard.ravenzwaay@basf-ag.de
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MeSH Terms
Descriptor/Qualifier:
2-Methyl-4-chlorophenoxyacetic Acid / chemistry,  metabolism*,  toxicity*
Acetic Acids / chemistry,  metabolism,  toxicity
Administration, Oral
Animals
Body Weight / drug effects
Bone Marrow / drug effects
Diet
Drinking / drug effects
Eating / drug effects
Female
Herbicides / metabolism,  toxicity*
Kidney / drug effects,  pathology
Male
Organ Size / drug effects
Plant Extracts / chemistry,  metabolism*
Rats
Rats, Wistar
Testis / drug effects
Toxicity Tests / classification,  methods
Urinalysis / methods
Chemical
Reg. No./Substance:
0/Acetic Acids; 0/Herbicides; 0/Plant Extracts; 122-59-8/phenoxyacetic acid; 94-74-6/2-Methyl-4-chlorophenoxyacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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